Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.

List of contents

Brief historical account of HBOC development.- Physiology of respiration.- Oxygen transport to tissues.- Pathophysiology of acute anemia.- Global blood safety and need for safe blood supply.- Blood transfusion and its limitations.- Scientific basis and design of HBOCs.- HBOCs: a regulatory perspective.- Current HBOC products in development.- Clinical indications and clinical trials of HBOCs.- HBOCs and adverse events observed in clinical trials.- HBOC-mediated vasoactivity and hypertension.- HBOC and oxygen and nitrogen radical mediated toxicity.- HBOCs and clinical laboratory interference.- Animal models for HBOC studies.- New emerging Technologies for universal RBCs.- Future prospects.

Product details

• Authors: A. Gerson Greenburg, Hae Won Kim
• Assisted by: Gerson Greenburg (Editor), Gerson Greenburg (Editor), A. Gerson Greenburg (Editor), Hae Won Kim (Editor), Ha Won Kim (Editor), Hae Won Kim (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 02.08.2013
• EAN: 9783642407161
• ISBN: 978-3-642-40716-1
• No. of pages: 746
• Dimensions: 169 mm x 241 mm x 44 mm
• Weight: 1318 g
• Illustrations: XXIII, 746 p. 130 illus., 77 illus. in color.
• Subjects: Natural sciences, medicine, IT, technology > Technology > Mechanical engineering, production engineering; Hämatologie, B, Medical research, Medizinische Chemie, Pharmazeutische Chemie, INTERNAL MEDICINE, Hematology, biochemistry, molecular biology, biotechnology, Chemistry and Materials Science, Biomedical Research, Biomaterials, Molecular Medicine, Haematology, MEDICINAL CHEMISTRY