Tissue and Organ Regeneration - Advances in Micro- and Nanotechnology

Edited by three of the top researchers in the field of tissue engineering and nanomedicine, with contributions from a team of pioneers and well-known leading experts in the biomedical field, this book presents the latest nano/microtechnologies used to manipulate stem cell behaviors, which is a critical area for regenerative medicine. It covers and details cutting-edge research in nano/microfabrication techniques and biomaterials for various tissue/organ, such as bone, cartilage, craniofacial, osteochondral, muscle, bladder and cardiovascular tissue, etc., regenerations.

List of contents

Nano and Microtechnology. Nano/Microfibrication Techniques for Tissue and Organ Regeneratio. Three Dimensional Micropatterning of Biomaterial Scaffolds for Tissue Engineering. Nanobiotechnology and Biomaterials for Regenerative Medicine. Micro- and Nanotechnology Engineering Strategies for Tissue Interface Regeneration and Repair. Spatiotemporal Genetic Control of Cellular Systems. Biomimetic Design of Extracellular Matrix-like Substrate for Tissue Regeneration. Degradable Elastomers for Tissue Regeneration. Protein Engineering Strategies for Modular, Responsive, and Spatially Organized Biomaterials. Tissue and Organ Regeneration. Design and Fabrication of Biomimetic Microvascular Architecture. The Self-Assembly Process of Articular Cartilage and Self-Organization in Tissue Engineering. Environmental Factors in Cartilage Tissue Engineering. Bone Regenerative Engineering: The Influence of Micro and Nano Dimension. Stem Cell and Bone Regeneration. Notch Signaling Biomaterials and Craniofacial Regeneration. Stem Cell-Based Dental, Oral and Craniofacial Tissue Engineering. Engineering Functional Bone Grafts for Craniofacial Regeneration. Nanotechnology in Osteochondral Regeneration. Aortic Heart Valve Tissue Regeneration. Micro and Nanotechnology in Vascular Regeneration. Micro- and Nanofabrication Approaches to Cardiac Tissue Engineering. Engineering of Skeletal Muscle Regeneration: Principles, Current State and Challenges.

About the author

Lijie Grace Zhang is assistant professor in the Department of Mechanical and Aerospace Engineering and the Department of Medicine at the George Washington University, USA. She is also director of the Bioengineering Laboratory for Nanomedicine and Tissue Engineering at the university.
Ali Khademhosseini is associate professor at the Harvard–MIT Division of Health Sciences and Technology, Brigham and Women’s Hospital, and Harvard Medical School as well as associate faculty at the Wyss Institute for Biologically Inspired Engineering, Harvard University, USA. He is also junior principal investigator at the World Premier International—Advanced Institute for Materials Research, Tohoku University, Japan, where he directs a satellite laboratory.
Thomas J. Webster is department chair of chemical engineering at Northeastern University, USA. His research explores the use of nanotechnology in numerous applications.

Summary

Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. The challenge for existing stem cell–based techniques is that current therapies lack controlled environments that are crucial for regulating stem cell engraftment and differentiation in vivo, because stem cells are rather sensitive to even minute changes in their environment. Micro- and nanotechnology hold great potential to fabricate biomimetic spatiotemporally controlled scaffolds as well as control stem cell behavior and fate by micro- and nanoscale cues.
This book presents the latest micro- and nanotechnologies used to manipulate stem cell behaviors, which is a critical area for regenerative medicine. Moreover, it covers and details cutting-edge research in nano- and microfabrication techniques and biomaterials for the regeneration of various tissues and organs, such as bone, cartilage, craniofacial, osteochondral, muscle, bladder, cardiac, and vascular tissues.

Additional text

"This practical tour de force will quickly bring you up to speed on the most recent tools and techniques for controlling cellular behavior. With contributions from internationally renowned authors, readers can explore a comprehensive collection of articles tailored for scientists, research engineers, and students to learn basic and advanced micro/nanotechnology protocols. The book helps professionals understand the many intricate steps involved in microenvironmental control in tissue engineering, focusing on state-of-the-art approaches for delivering soluble and substrate-based cues to cells. If you have an interest in tissue engineering or regenerative medicine, this book is a must-have!"

Prof. Jeffrey M. Karp, Brigham and Women's Hospital, USA

Product details

• Assisted by: Ali Khademhosseini (Editor), Thomas Webster (Editor), Thomas J. Webster (Editor), Lijie Grace Zhang (Editor)
• Publisher: Taylor and Francis
• Languages: English
• Product format: Hardback
• Released: 15.05.2014
• EAN: 9789814411677
• ISBN: 978-981-4411-67-7
• No. of pages: 822
• Dimensions: 152 mm x 229 mm x 48 mm
• Weight: 1292 g
• Illustrations: Farb., s/w. Abb.
• Subject: Natural sciences, medicine, IT, technology > Physics, astronomy > Atomic physics, nuclear physics