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Aldol Reactions provides a comprehensive up-to-date overview of aldol reactions including application of different metal enolates; catalytic aldol additions catalyzed by different Lewis acids and Lewis bases; enantioselective direct aldol additions; antibodies and enzyme catalyzed aldol additions and the recent aggressive development of organocatalyzed aldol additions.
The power of each method is demonstrated by several applications in total synthesis of natural products. The pros and cons of these methodologies with regard to stereoselectivity, regioselectivity and application in total synthesis of natural products are discussed. Great importance is set to the diverse possibilities of the manual of aldol reaction to install required configurations in complicated natural product synthesis.
List of contents
Aldol Reactions with Preformed Enolates.- Magnesium Enolates.- Boron Enolates.- Titanium Enolates.- Tin Enolates.- Catalytic Aldol Additions.- Lewis Acid-Catalysed Aldol Reactions.- Tin Lewis Acids.- Boron Lewis Acids.- Copper Lewis Acids.- Silver, Palladium and Platinum Lewis Acids.- Zirconium Lewis Acids.- Miscellaneous Lewis Acids.- Lewis Base-Catalysed Aldol Additions.- Direct Aldol Addition.- Gold- and Rhodium-Catalysed Aldol Additions.- Antibody-Catalysed Aldol Addition.- Enzyme-Catalysed Aldol Addition.- Organocatalysed Aldol Addition.
About the author
Dr. Rainer Mahrwald was born in 1950. He studied chemistry at MLU Halle and subsequently joined the Manfred von Ardenne Research Institute in Dresden, where he led the synthetics group. He gained his doctorate under G. Wagner in Leipzig in 1979, and went on to the Institute of Organic Chemistry at the Academy of Science in Berlin, where he remained until 1990. Following a stay at the Philipps-University in Marburg, Dr. Mahrwald qualified as a lecturer at the Humboldt University Berlin, where he is now a lecturer.
Summary
Aldol Reactions provides a comprehensive up-to-date overview of aldol reactions including application of different metal enolates; catalytic aldol additions catalyzed by different Lewis acids and Lewis bases; enantioselective direct aldol additions; antibodies and enzyme catalyzed aldol additions and the recent aggressive development of organocatalyzed aldol additions.
The power of each method is demonstrated by several applications in total synthesis of natural products. The pros and cons of these methodologies with regard to stereoselectivity, regioselectivity and application in total synthesis of natural products are discussed. Great importance is set to the diverse possibilities of the manual of aldol reaction to install required configurations in complicated natural product synthesis.
