Cardiac Regeneration and Repair - Pathology and Therapies

Klappentext Heart disease is the leading cause of death in the UK and the United States. For those people who survive heart disease! few victims recover completely. Cell therapies! tissue engineering and biomaterials technologies have advanced and now offer the potential to reverse the damage caused by heart disease. Volume 1 of this important book provides readers with comprehensive information on the pathology of heart disease and the cell therapies available. Opening chapters look at cardiac pathology and current therapies. Further chapters present gene and protein therapies for regeneration. The text then discusses cell therapies for cardiac regeneration whilst final chapters review clinical considerations of stem cell therapies. Inhaltsverzeichnis Contributor contact details Woodhead Publishing Series in Biomaterials Foreword Introduction Part I: The pathogenesis of congestive heart failure Chapter 1: Cardiac matrix remodeling and heart failure Abstract: 1.1 Introduction 1.2 Cardiac matrix remodeling in the development and progression of heart failure (HF) after myocardial infarction (MI) 1.3 Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in matrix and cardiac remodeling 1.4 Role of inflammation in matrix and cardiac remodeling 1.5 Role of monocytes and macrophages in matrix and cardiac remodeling 1.6 Extracellular matrix (ECM) and collagen deposition 1.7 Treatment strategies and considerations 1.8 Future trends 1.9 Acknowledgments Chapter 2: Cardiac biomechanics and heart dysfunction Abstract: 2.1 Introduction 2.2 Measures of cardiac biomechanics 2.3 Techniques for assessing the parameters used to quantify cardiac function 2.4 Passive versus active cardiac function 2.5 Effects of ischemia and infarction on cardiac biomechanics 2.6 Conclusion Chapter 3: Modifying matrix remodeling to prevent heart failure Abstract: 3.1 Introduction 3.2 Clinical progress and remaining issues 3.3 Extracellular matrix (ECM) remodeling in the post-myocardial infarction setting 3.4 Cells that modify ECM remodeling 3.5 Therapeutic options 3.6 Future trends 3.7 Conclusion 3.8 Sources of further information and advice 3.9 Acknowledgements Part II: Cell therapy for cardiac regeneration and repair Chapter 4: Optimal cells for cardiac repair and regeneration Abstract: 4.1 Introduction 4.2 Cell candidates for the repair of ischemic myocardium 4.3 Mechanisms of stem cell transplantation for myocardium repair 4.4 Overview of the centers for cardiac cell transplantation 4.5 Conclusion and future trends 4.7 Appendix: abbreviations and acronyms Chapter 5: Cell delivery routes for cardiac stem cell therapy Abstract: 5.1 Introduction 5.2 Intravenous (IV) injection for cell therapy to the heart 5.3 Intramyocardial (IM) injection for cell therapy to the heart 5.4 Intracoronary (IC) injection for cell therapy to the heart 5.5 Advanced methods for cell therapy to the heart: tissue engineering and the cell-sheet technique 5.6 Conclusion and future trends 5.7 Acknowledgment Chapter 6: Cell therapy to regenerate the ischemic heart Abstract: 6.1 Introduction 6.2 Pathology of ischemic damage 6.3 Goals and mechanisms of cell therapy to regenerate the ischemic heart 6.4 Candidate populations for cell therapy 6.5 Variables of cell therapy 6.6 Conclusion Chapter 7: Cell therapy for cardiac repair - bench to bedside and back Abstract: 7.1 Introduction 7.2 Transition of stem cell therapeutics from the bench to the clinic 7.3 Skeletal myoblasts 7.4 Hematological stem cell (HSC) products 7.5 Conclusion Chapter 8: Recent advances in cardiac stem cell therapy to restore left ventricular function Abstract: 8.1 Introduction 8.2 The disputed existence of cardiac stem cells (CSCs) 8.3 Therapeutic application of CSCs to restore ventricular function 8.4 Future trends 8.5 Conclusion Chapter 9: Monitoring myocardial functiona...

List of contents

• Contributor contact details
• Woodhead Publishing Series in Biomaterials
• Foreword
• Introduction
• Part I: The pathogenesis of congestive heart failure
  • Chapter 1: Cardiac matrix remodeling and heart failure
    • Abstract:
    • 1.1 Introduction
    • 1.2 Cardiac matrix remodeling in the development and progression of heart failure (HF) after myocardial infarction (MI)
    • 1.3 Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in matrix and cardiac remodeling
    • 1.4 Role of inflammation in matrix and cardiac remodeling
    • 1.5 Role of monocytes and macrophages in matrix and cardiac remodeling
    • 1.6 Extracellular matrix (ECM) and collagen deposition
    • 1.7 Treatment strategies and considerations
    • 1.8 Future trends
    • 1.9 Acknowledgments
  • Chapter 2: Cardiac biomechanics and heart dysfunction
    • Abstract:
    • 2.1 Introduction
    • 2.2 Measures of cardiac biomechanics
    • 2.3 Techniques for assessing the parameters used to quantify cardiac function
    • 2.4 Passive versus active cardiac function
    • 2.5 Effects of ischemia and infarction on cardiac biomechanics
    • 2.6 Conclusion
  • Chapter 3: Modifying matrix remodeling to prevent heart failure
    • Abstract:
    • 3.1 Introduction
    • 3.2 Clinical progress and remaining issues
    • 3.3 Extracellular matrix (ECM) remodeling in the post-myocardial infarction setting
    • 3.4 Cells that modify ECM remodeling
    • 3.5 Therapeutic options
    • 3.6 Future trends
    • 3.7 Conclusion
    • 3.8 Sources of further information and advice
    • 3.9 Acknowledgements
• Part II: Cell therapy for cardiac regeneration and repair
  • Chapter 4: Optimal cells for cardiac repair and regeneration
    • Abstract:
    • 4.1 Introduction
    • 4.2 Cell candidates for the repair of ischemic myocardium
    • 4.3 Mechanisms of stem cell transplantation for myocardium repair
    • 4.4 Overview of the centers for cardiac cell transplantation
    • 4.5 Conclusion and future trends
    • 4.7 Appendix: abbreviations and acronyms
  • Chapter 5: Cell delivery routes for cardiac stem cell therapy
    • Abstract:
    • 5.1 Introduction
    • 5.2 Intravenous (IV) injection for cell therapy to the heart
    • 5.3 Intramyocardial (IM) injection for cell therapy to the heart
    • 5.4 Intracoronary (IC) injection for cell therapy to the heart
    • 5.5 Advanced methods for cell therapy to the heart: tissue engineering and the cell-sheet technique
    • 5.6 Conclusion and future trends
    • 5.7 Acknowledgment
  • Chapter 6: Cell therapy to regenerate the ischemic heart
    • Abstract:
    • 6.1 Introduction
    • 6.2 Pathology of ischemic damage
    • 6.3 Goals and mechanisms of cell therapy to regenerate the ischemic heart
    • 6.4 Candidate populations for cell therapy
    • 6.5 Variables of cell therapy
    • 6.6 Conclusion
  • Chapter 7: Cell therapy for cardiac repair - bench to bedside and back
    • Abstract:
    • 7.1 Introduction
    • 7.2 Transition of stem cell therapeutics from the bench to the clinic
    • 7.3 Skeletal myoblasts
    • 7.4 Hematological stem cell (HSC) products
    • 7.5 Conclusion
  • Chapter 8: Recent advances in cardiac stem cell therapy to restore left ventricular function
    • Abstract:
    • 8.1 Introduction
    • 8.2 The disputed existence of cardiac stem cells (CSCs)
    • 8.3 Therapeutic application of CSCs to restore ventricular function
    • 8.4 Future trends
    • 8.5 Conclusion
  • Chapter 9: Monitoring myocardial functional regeneration following cardiac stem cell application
    • Abstract:
    • 9.1 Introduction
    • 9.2 Conventional functional monitoring modalities following cardiac cell application
    • 9.3 Evolving imaging modalities for the assessment of myocardial regeneration
    • 9.4 Conclusion and future trends
  • Chapter 10: Feasibility of allogeneic stem cells for heart regeneration
    • Abstract:
    • 10.1 Introduction
    • 10.2 Characteristics and isolation of mesenchymal stem cells (MSCs)
    • 10.3 In vivo studies of allogeneic MSCs
    • 10.4 Mechanisms of allogeneic MSC therapy
    • 10.5 Future trends
    • 10.6 Sources of further information and advice
  • Chapter 11: Bone marrow cells and their role in cardiac repair after myocardial infarction
    • Abstract:
    • 11.1 Heart disease in the United States
    • 11.2 History of bone marrow stem cells
    • 11.3 Stem cell niche in the bone marrow
    • 11.4 Delivery of bone marrow stem cells to the heart
    • 11.5 Clinical trials of bone marrow stem cell therapy
    • 11.6 Limitations of bone marrow stem cell therapy
    • 11.7 Conclusion
• Part III: Stem cells for cardiac regeneration and repair
  • Chapter 12: Cardiac cell therapy to restore contracting elements
    • Abstract:
    • 12.1 Introduction
    • 12.2 Contractile elements and their importance in normal cardiac function
    • 12.3 Evidence that cellular therapies can restore cardiac contractility
    • 12.4 Future trends
    • 12.5 Sources of further information and advice
  • Chapter 13: Human embryonic stem cells (hESCs) for heart regeneration
    • Abstract:
    • 13.1 Introduction
    • 13.2 Rationale for using embryonic stem cells (ESCs) to treat severe heart failure
    • 13.3 ESCs for severe heart failure: preclinical data
    • 13.4 ESCs for severe heart failure: specific translational issues
    • 13.5 Issues common to all cell therapy products
    • 13.6 Future trends
    • 13.7 Conclusion
    • 13.8 Sources of further information and advice
  • Chapter 14: Human pluripotent stem cells (hPSCs) for heart regeneration
    • Abstract:
    • 14.1 Introduction
    • 14.2 Background to cardiovascular disease and cardiac remodeling and repair
    • 14.3 Cardiovascular developmental bioengineering
    • 14.4 Cardiac disease modeling with human induced pluripotent stem cells
    • 14.5 Conclusion
  • Chapter 15: Cardiac cell therapy: current status and future trends
    • Abstract:
    • 15.1 Introduction
    • 15.2 Current cell delivery methods
    • 15.3 Cell types for cardiac regeneration
    • 15.4 In vivo cell tracking
    • 15.5 Evaluation of heart function
    • 15.6 Cardiac cell therapy issues
    • 15.7 Future trends
• Part IV: Gene therapy for cardiac regeneration and repair
  • Chapter 16: Stem cell and gene therapy for cardiac regeneration
    • Abstract:
    • 16.1 Introduction
    • 16.2 Non-cardiac progenitor cells
    • 16.3 Cardiac stem cells (CSCs)
    • 16.4 Mechanisms of cardiac regeneration
    • 16.5 Mechanisms of cardiac gene transfer
    • 16.6 Conclusion and future trends
  • Chapter 17: Ultrasound-targeted cardiovascular gene therapy
    • Abstract:
    • 17.1 Introduction
    • 17.2 Ultrasound-mediated gene delivery (UMGD)
    • 17.3 Microbubble carrier agents
    • 17.4 Gene/nucleic acid vectors
    • 17.5 Ultrasound and bioeffects
    • 17.6 Experimental considerations and protocols
    • 17.7 Therapeutic applications of UMGD
    • 17.8 Future trends
• Index

Report

"This book not only serves as an invaluable resource for enhancing understanding in this field, it also provides an outstanding basis for further research. Score: 88 - 3 Stars"-- Doodys.com , January 16, 2015

Product details

• Authors: Ren-Ke Li, Ren-ke (EDT)/ Weisel Li, Ren-Ke Weisel Li
• Assisted by: Ren-Ke Li (Editor), Richard D. Weisel (Editor)
• Publisher: ELSEVIER SCIENCE BV
• Languages: English
• Product format: Hardback
• Released: 22.01.2014
• EAN: 9780857096586
• ISBN: 978-0-85709-658-6
• No. of pages: 440
• Series: Woodhead Publishing Series in Biomaterials; Woodhead Publishing; Woodhead Publishing Series in Biomaterials; Woodhead Publishing Biomateria
• Subject: Natural sciences, medicine, IT, technology > Medicine