Pain Genetics - Basic to Translational Science

Informationen zum Autor Inna Belfer , MD, PhD, is an Associate Professor of Anesthesiology and Human Genetics and Director of the Molecular Epidemiology of Pain Program at the Department of Anesthesiology, School of Medicine, University of Pittsburgh. Luda Diatchenko , MD, PhD, is a Canada Excellence Research Chair in Human Pain Genetics, Professor, Faculty of Medicine, Department of Anesthesia, and Faculty of Dentistry at McGill University, Alan Edwards Centre for Research on Pain. Klappentext Pain Genetics: Basic to Translational Science is a timely synthesis of the key areas of research informing our understanding of the genetic basis of pain. The book opens with foundational information on basic genetic mechanisms underlying pain perception and progresses recently discovered complex concepts facing the field. The coverage is wide-ranging and will serves as an excellent entry point into understating the genetics of pain as well as providing a single resource for established researchers looking for a better understanding of the diverse strands of research going on in the area.With contributors painstakingly selected to provide a broad range of perspectives and research, Pain Genetics will be a valuable resource for geneticists, neuroscientists, and biomedical professionals alike. Zusammenfassung Pain Genetics: Basic to Translational Science is a timely synthesis of the key areas of research informing our understanding of the genetic basis of pain. The book opens with foundational information on basic genetic mechanisms underlying pain perception and progresses recently discovered complex concepts facing the field. Inhaltsverzeichnis Editors' Biographies xi Contributors xiii 1 How Do Pain Genes Affect Pain Experience? 1 Marshall Devor Introduction 2 Heritability of Pain: Historical Roots 2 Why is Pain Genetics Interesting and Potentially Useful? 4 What Are Pain Genes? 8 How Do Pain Genes Affect Pain Experience? 9 Disease Susceptibility Genes Versus Pain Susceptibility Genes 12 Perspective 13 Acknowledgments 13 2 Conservation of Pain Genes Across Evolution 15 Thang Manh Khuong and G. Greg Neely Introduction 15 Anatomical Organization of Nociception Apparatus in Mammals and Drosophila 16 Acute Heat Pain in Mammals 16 Acute Heat Nociception in Drosophila 18 Mechanical Pain in Mammals 19 Mechanical Nociception in Drosophila 19 Chemical Nociception in Mammals 21 Chemical Nociception in Drosophila 21 Inflammatory Pain in Mammals 22 Persistent Pain in Drosophila 22 Neuropathic Pain in Mammals 25 Structural Reorganizations of Nerve Fibers in Neuropathic Pain 25 Mammalian Neuropathic Pain Genes That Are Conserved in Drosophila 25 Long-Term Potentiation and Long-Term Depression in Neuropathic Pain in Mammals 28 Neuropathic Pain in Drosophila 30 Conclusions 30 3 Defining Human Pain Phenotypes for Genetic Association Studies 37 Christopher Sivert Nielsen Introduction 37 What is a Pain Phenotype? 38 Pain Scaling 39 Heritability 40 Genotype-Phenotype Matching 41 Reliability and Temporal Stability 41 Clinical Phenotypes 43 Designing Clinical Pain Genetic Studies 43 The Heritability of Specific Clinical Pain Conditions 45 Experimental Phenotypes 45 The Heritability of Experimental Phenotypes 46 Extended Phenotypes 47 Practical Concerns 47 Conclusions 48 Conflict of Interest Statement 48 4 Genetic Contributions to Pain and Analgesia: Interactions with Sex and Stress 51 Roger B. Fillingim and Jeffrey S. Mogil Introduction 51 Brief Overview of Sex and Gender Differences in Pain and An...

List of contents

Editors' Biographies xi
 
Contributors xiii
 
1 How Do Pain Genes Affect Pain Experience? 1
Marshall Devor
 
Introduction 2
 
Heritability of Pain: Historical Roots 2
 
Why is Pain Genetics Interesting and Potentially Useful? 4
 
What Are Pain Genes? 8
 
How Do Pain Genes Affect Pain Experience? 9
 
Disease Susceptibility Genes Versus Pain Susceptibility Genes 12
 
Perspective 13
 
Acknowledgments 13
 
2 Conservation of Pain Genes Across Evolution 15
Thang Manh Khuong and G. Greg Neely
 
Introduction 15
 
Anatomical Organization of Nociception Apparatus in Mammals and Drosophila 16
 
Acute Heat Pain in Mammals 16
 
Acute Heat Nociception in Drosophila 18
 
Mechanical Pain in Mammals 19
 
Mechanical Nociception in Drosophila 19
 
Chemical Nociception in Mammals 21
 
Chemical Nociception in Drosophila 21
 
Inflammatory Pain in Mammals 22
 
Persistent Pain in Drosophila 22
 
Neuropathic Pain in Mammals 25
 
Structural Reorganizations of Nerve Fibers in Neuropathic Pain 25
 
Mammalian Neuropathic Pain Genes That Are Conserved in Drosophila 25
 
Long-Term Potentiation and Long-Term Depression in Neuropathic Pain in Mammals 28
 
Neuropathic Pain in Drosophila 30
 
Conclusions 30
 
3 Defining Human Pain Phenotypes for Genetic Association Studies 37
Christopher Sivert Nielsen
 
Introduction 37
 
What is a Pain Phenotype? 38
 
Pain Scaling 39
 
Heritability 40
 
Genotype-Phenotype Matching 41
 
Reliability and Temporal Stability 41
 
Clinical Phenotypes 43
 
Designing Clinical Pain Genetic Studies 43
 
The Heritability of Specific Clinical Pain Conditions 45
 
Experimental Phenotypes 45
 
The Heritability of Experimental Phenotypes 46
 
Extended Phenotypes 47
 
Practical Concerns 47
 
Conclusions 48
 
Conflict of Interest Statement 48
 
4 Genetic Contributions to Pain and Analgesia: Interactions with Sex and Stress 51
Roger B. Fillingim and Jeffrey S. Mogil
 
Introduction 51
 
Brief Overview of Sex and Gender Differences in Pain and Analgesia 52
 
Brief Overview of Stress and Pain/Analgesia 52
 
Sex X Gene Interactions in Pain and Analgesia 53
 
Summary 57
 
5 Abnormal Pain Conditions in Humans Related to Genetic Mutations 61
Christopher Geoffrey Woods
 
Introduction to SCN9A, NTRK1, and NGF and the Roles They Play in Pain 61
 
Introduction to SCN9A and Its Omnipotent Role in Pain Sensing 62
 
Introduction to NTRK1 and Its Role in Development and Function in the Pain and Sympathetic Nervous Systems 69
 
Introduction to NGF, the First Nerve Growth Factor to Be Found and Studied 72
 
6 Alternative Pre-mRNA Splicing of Mu Opioid Receptor Gene: Molecular Mechanisms Underlying the Complex Actions of Mu Opioids 79
Ying-Xian Pan
 
Introduction 79
 
Evolution of OPRM1 Gene 80
 
OPRM1 Gene: Chromosomal Location and Gene Structure 82
 
Alternative Promoters 82
 
Alternative Pre-mRNA Splicing of the OPRM1 Gene 83
 
Expression and Function of the OPRM1 Splice Variants 90
 
Conclusion 94
 
7 Discovering Multilocus Associations with Complex Pain Phenotypes 99
Chia-Ling Kuo, Luda Diatchenko, and Dmitri Zaykin
 
Introduction 99
 
Approaches Based on Testing Individual Genetic Variants Within a Region 100
 
Approaches That Combine Association Signals Across Genetic Variants 101
 
Methods for Testing Joint Eff

Product details

• Authors: I Belfer, Inna Belfer, Inna Diatchenko Belfer, Luda Diatchenko, Inna Belfer
• Assisted by: Inn Belfer (Editor), Inna Belfer (Editor), Belfer Inna (Editor), Diatchenko (Editor), Diatchenko (Editor), Luda Diatchenko (Editor), Diatchenko Luda (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 31.01.2014
• EAN: 9781118398845
• ISBN: 978-1-118-39884-5
• No. of pages: 204
• Subjects: Natural sciences, medicine, IT, technology > Biology > Genetics, genetic engineering; Life Sciences, Humangenetik, Biowissenschaften, Human Genetics, Medical Genetics, Medizinische Genetik, Neurogenetik, Neurogenetics