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Klappentext Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists. "This book is a very substantial contribution to our understanding of many aspects of these very interesting, important, and related cells - the mast cell and basophil. But for the fact that this field, like so many others, is changing so rapidly, this volume will be the standard against which others will be compared for several years to come. It is a 'must have' for any life science or medical library." --ALVIN TESLER in DOODY'S HEALTH SCIENCES BOOK REVIEW JOURNAL Zusammenfassung A study of mast cells and basophils. The chapters cover all aspects of mast cell and basophil research! from cell development! proteases! histamine! cysteinyl leukotrienes! physiology and pathology to the role of these cells in health and disease. Inhaltsverzeichnis Contributors Preface Acknowledgments Section One Development of Mast Cells and Basophils Chapter 1 Regulation of Mast Cell and Basophil Development by Stem Cell Factor and Interleukin-3 Introduction SCF, a Ligand for the c-kit Receptor Multiple Effects of SCF in Mast Cell Biology SCF can Regulate Mast Cell Function In Vitro and In Vivo Interleukin-3 Using IL-3-/- Mice to Assess the Role of IL-3 in Mast Cell and Basophil Development Summary Acknowledgments References Chapter 2 Gain-of-function Mutations of c-kit in Human Diseases Introduction Loss-of-function Mutation of c-kit Stomach Lesions of W/Wv and SI/SId Mice Gain-of-function Mutation of c-kit in Mast Cell Neoplasms Sporadic Gastrointestinal Stromal Turnouts Familial GIST Conclusion References Chapter 3 Modulation of Mast Cell Development from Embryonic Haematopoietic Progenitors by Eotaxin Chemokines and Their Receptors Play Diverse Roles as Mediators of Inflammation Chemokines Participate in Multiple Mast Cell and Basophil Functions Chemokine Secretion by Mast Cells Eotaxin Results Discussion References Chapter 4 Regulation and Dysregulation of Mast Cell Survival and Apoptosis Introduction Regulation of Mast Cell Survival and Apoptosis by Growth Factors Regulation of Mast Cell Survival and Apoptosis by Death Receptors Regulation of Mast Cell Survival and Apoptosis by Perforin, Nitric Oxide and Bacterial Toxins Regulation of Mast Cell Survival and Apoptosis by Irradiation and Chemical Agents Perspective: Apoptosis and Mast Cell Disease References Section Two Phenotypic and Ultrastructural Features of Mast Cells and Basophils Chapter 5 Ultrastructural Features of Human Basophil and Mast Cell Secretory Function Introduction Mechanism(s) of Histamine and CLC-P Secretion from Human Basophils, of Histamine Secretion from Human Mast Cells In Vitro and of TNF-¿ and Chymase Secretion from Rat Peritoneal Cells Histamine Secretion from Human Mast Cells In Vivo Heparin Secretion from Human Mast Cells In Vitro The Vesiculovacuolar Organelle, a New Endothelial Permeability Structure Acknowledgments References Chapter 6 Human Dendritic Mast Cells Introduction The Morphology of Human Dendritic Mast Cells Functional Aspects and Future Lines of Research Concluding Remarks References Chapter 7 The Phenotypic Similarities and Differences between Human Basophils and Mast Cells Introduction Morphology Membrane Receptors Cytoplasmic Contents Mast Cell Phenotypes in Tissues The Involvement of Mast Cells and Basophils in Asthma and Drug Reactions Ackn...
