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Immunopharmacology represents the boundary between the immune system and chemical mediators of the inflammatory and neuroendocrine responses. The subject as applied to the respiratory system embraces most of the common non-malignant lung diseases of which asthma and allied disorders are the most prevalent. An understanding of the underlying mechanisms of the disorders provides rationale for prevention and drug treatment as well as creating opportunities for novel drug development.
Immunopharmacology of Respiratory System embraces all of these principles and should enable the reader to become rapidly updated in an area of medical importance.
List of contents
Macrophages and Dendritic Cell Populations in the Respiratory Tract. The Role of T Lymphocytes in Mucosal Protection and Injury. The Regulation of Immunoglobulin-E Synthesis. Mast Cells and Basophils: Their Role in Initiating and Maintaining Inflammatory Responses. Eosinophils: Effector Leukocytes of Allergic Inflammatory Responses. Cytokine Regulation of Chronic Inflammation in Asthma. Neural Networks in the Lung. The Microvasculature as a Participant in Inflammation. Regulation of Airway Smooth Muscle. The Airway Epithelium: The Origin and Target of Inflammatory Airways Disease and Injury. Transition Between Inflammation and Fibrosis in the Lung. The Cell Biology of the Resolution of Inflammation.
About the author
Stephen T. Holgate is a Clinical Professor of Immunopharmacology at Southampton General Hospital.Professor Clive P. Page, BSc PhD OBE HonFBPhS is a Professor of Pharmacology, King’s College London and Director of the Sackler Institute of Pulmonary Pharmacology, King’s College London. Clive’s main research interests are in the pharmacology of inflammation and respiratory disease and he has published over 250 scientific papers. Clive was the co-founder and previous Chairman of the Board of Verona Pharma plc, an AIM listed Company developing new drugs for the treatment of Respiratory Diseases. He is a Non Executive Director of and on boards of several companies. He was awarded the Society of Biology President’s Medal in 2012 for an outstanding contribution to the life sciences over the previous year. He is a Fellow of the Royal Society of Biology and an Honorary Fellow and President Elect of the British Pharmacological Society. In 2017, Clive was awarded an OBE for Services to Pharmacology.
Summary
Immunopharmacology represents the boundary between the immune system and chemical mediators of the inflammatory and neuroendocrine responses. This volume focuses on aspects of disease pathogenesis that are common to a variety of lung disorders. It also covers the mechanisms of asthma - origin, progression, and novel therapeutic interventions.
