Transmitters and Modulators in Health and Disease - New Frontiers in Neuroscience

Prominent international researchers contributed to this volume of reports advancing the study of brain function and morphology. Comprising investigations in several areas of neuroscience, the book includes research in neurodegenerative diseases and in neuroregeneration in adults. Described here are the effects of neuropeptides and biogenic amines on feeding, respiration, and other autonomic functions as well as on behavior. One chapter focuses on regulation of the blood brain barrier function by various neuropeptides, proteins, receptors, and transporters. Another is concerned with the modulation of higher brain functions by neuropeptides and biogenic monoamines. Yet another chapter presents research on ischemic neuronal damage and hippocampal neurogenesis in the adult mouse. Morphological or physiological techniques to study neuropeptides and neuromodulators influencing higher-order or brain-stem functions are given particular attention. The use of bio-imaging tools such as brain navigation systems and fMRIs with patients in a clinical setting creates new possibilities for investigation of human brain function and specialization of treatment.

List of contents

Neuropeptides and Behavior.- Evolution of neuropeptide concepts illustrated by MIF-1 and MSH.- Increased leptin supply to hypothalamus by gene therapy confers life-long benefits on energy homeostasis, disease cluster of metabolic syndrome- diabetes type 1 and 2, dyslipidemia and cardiovascular ailments- and bone remodeling.- Feeding regulation in the brain: Involvement of Neuropeptide W.- Feeding regulation in the brain: Role of galanin-like peptide (GALP).- Neuropeptides, Bioamines, and Clinical Implications.- Neuropeptide Y and its Role in Anxiety-related Disorders.- The search for a fetal origin for autism: Evidence of aberrant brain development in a rat model of autism produced by prenatal exposure to valproate.- Sexually dimorphism and social brain circuit: Its implication to Autism.- Functional Mapping of Sensory and Motor Brain Activity.- Stimulating Music: Combining Melodic Intonation Therapy with Transcranial DC Stimulation to Facilitate Speech Recovery after Stroke.- Serotonin release acts on 5-HT2 receptors in the dorsomedial medulla oblongata to elicit airway dilation in mice.- Breathing is to live, to smell and to feel.- Role of the medial frontal wall for readiness of motor execution.- Poster Presentations.- Ryanodine receptor type 1 / calcium release channel in the endoplasmic reticulum as the target of nitric oxide to cause the intracellular calcium signaling.- Decreased sensitivity to negative facial emotions and limbic lesions in patients with myotonic dystrophy type 1.- Generation of Rac1 conditional mutant mice by Cre/loxP system.- Orexin modulates neuronal activities of mesencephalic trigeminal sensory neurons in rats.- Investigation of the anxiolytic effects of Kampo formulation, Kamishoyosan, used for treating menopausal psychotic syndromes in women.- Activation of Microglia Induced Learning and Memory Deficits.- Increased behavioral activity with regular circadian rhythm in PACAP specific receptor (PAC1) transgenic mice.- Expression and localization of pituitary adenylate cyclase-activating polypeptide (PACAP) specific receptor (PAC1R) after traumatic brain injury in mice.

Summary

Prominent international researchers contributed to this volume of reports advancing the study of brain function and morphology. Comprising investigations in several areas of neuroscience, the book includes research in neurodegenerative diseases and in neuroregeneration in adults. Described here are the effects of neuropeptides and biogenic amines on feeding, respiration, and other autonomic functions as well as on behavior. One chapter focuses on regulation of the blood brain barrier function by various neuropeptides, proteins, receptors, and transporters. Another is concerned with the modulation of higher brain functions by neuropeptides and biogenic monoamines. Yet another chapter presents research on ischemic neuronal damage and hippocampal neurogenesis in the adult mouse. Morphological or physiological techniques to study neuropeptides and neuromodulators influencing higher-order or brain-stem functions are given particular attention. The use of bio-imaging tools such as brain navigation systems and fMRIs with patients in a clinical setting creates new possibilities for investigation of human brain function and specialization of treatment.

Product details

• Assisted by: Iku Homma (Editor), Ikuo Homma (Editor), Nobumasa Kato (Editor), Seiji Shioda (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 11.05.2011
• EAN: 9784431998662
• ISBN: 978-4-431-99866-2
• No. of pages: 212
• Weight: 369 g
• Illustrations: XXIII, 212 p.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; C, Medicine, Neurology, Psychiatry