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"This question-and-answer guide on metalloproteins reflects the broad range of aspects within this branch of protein science. It is divided into seven parts, addressing: the cell, the alkali and alkaline earth cations, non-redox metalloenzymes, carboxypeptases, carbonic anhydrase, alcohol dehydrogenase, copper proteins, electronic and ESR spectra of copper ions, plastocyanin, stellacyanin, superoxide dismutase, electronic spectra of iron ions, Mossbauer spectroscopy of iron ions, ESR spectra of Iion (III), iron bioavailability, siderophores, non-heme iron proteins, ferritin, transferrin, dioxygenase-iron proteins, rubredoxin, 2Fe-2S Ferredoxins, 4FE-4S Ferredoxins and hiPIP, aconitase, hydroxylases, hydrogenases, nitrogenases, binuclear Fe proteins, hemerythrin, ribotide reductase, purple acid phosphate and methane mono-oxygenase, heme proteins, myoglobin and hemoglobin, electronic spectra of hemoproteins, cytochrome C, peroxidase, cytochrome P450, ESR spectra of hemoproteins, vitamin B12, and chlorophyll. Each section ends with suggestions for further reading"--Provided by publisher.
List of contents
Preface ix
1 Introduction 1
Proteins: Formation, Structures, and Metalloproteins, 4
References, 28
2 Alkali and Alkaline Earth Cations 31
References, 67
3 Nonredox Metalloenzymes 71
Carboxypeptidases, 75
Carbonic Anhydrase, 84
Alcohol Dehydrogenase, 88
References, 91
4 Copper Proteins 95
Introduction, 95
Electronic Spectra of Copper Ions, 96
ESR Spectra of Copper Ions, 105
Copper Proteins, 117
Plastocyanin, 119
Azurin and Stellacyanin, 127
Superoxide Dismutase, 131
Hemocyanin, 135
Ascorbic Oxidase, 139
References, 142
5 Iron Proteins 147
Introduction, 147
Electronic Spectra of Iron Ions, 148
Mössbauer Spectroscopy of Iron Ions, 155
ESR Spectra of Iron (III), 161
Iron Bioavailability, 166
Siderophores, 171
Iron Storage and Transfer Proteins, 184
Ferritin, 184
Transferrin, 187
Dioxygenase Iron Proteins, 195
Iron-Sulfur Proteins, 207
Rubredoxin, 207
Ferredoxins, 212
2Fe-2S Ferredoxins, 212
4Fe-4S Ferredoxins, 221
Aconitase, 226
Hydroxylases, 229
Hydrogenases, 232
Nitrogenases, 240
Binuclear Iron Proteins, 251
Hemerythrin, 253
Ribotide Reductase, Purple Acid Phosphate, and Methane Monooxygenase, 260
Hemoproteins: Classification and Behavior of Heme in Absence of Globins, 267
Myoglobin and Hemoglobin, 275
Myoglobin, 275
Hemoglobin, 280
Cytochrome C, 298
Electron Transfer in Porphyrins and Metalloporphyrins, 301
Catalases, 311
Peroxidases, 315
Cytochrome P-450, 322
Electronic Spectra of Hemoproteins, 327
ESR Spectra of Hemoproteins, 362
References, 378
6 Vitamin B12 393
References, 405
7 Chlorophyll 407
References, 421
Index 423
About the author
JOSEPH J. STEPHANOS, PHD, is Associate Professor of Bioinorganic, Biophysical, and Inorganic Chemistry at Menofia University. His research examines metalloprotein chemistry, ligand-binding, and coordination chemistry of biologically active compounds.
ANTHONY W. ADDISON, PHD, is Professor of Inorganic Chemistry at Drexel University. His research focuses on bioinorganic chemistry; chemistry of dioxygen- and NO-binding metalloproteins; and the design, synthesis, and properties of novel chelating agents and macrocyclic and oligonuclear metal complexes. His numerous research articles and conference presentations have earned over 8,000 citations and a Hirsch Index of 37.
Summary
Addresses the full gamut of questions in metalloprotein science. This book examines all major families of metal binding proteins, presenting our understanding of their structural, physicochemical, and functional properties. It introduces medical applications of metalloproteins.
