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This book will comprehensively cover the most updated knowledge on the role of non-coding RNAs in human cancer. The Reader will be guided from the definition of what non-coding RNAs are to the translational and therapeutic implications of these fascinating molecules for cancer patients, through some of the most important discoveries clarifying the role of non-coding RNAs in human carcinogenesis. Although most of the current discoveries involve microRNAs (miRNAs), other non-coding RNA, with a proven involvement in human cancer, will be covered by this book, which will therefore represent the first, extensive publication on the whole category of non-coding RNAs in human cancer.
List of contents
Introduction.- Biogenesis and Physiology of microRNAs.-Detecting non-coding RNA expression: from arrays to next generation sequencing.- MicroRNAs in Solid Tumors.-MicroRNAs in hematologic malignancies.- miRNAs as Cancer Biomarkers.- Unraveling the complex network of interactions between non-coding RNAs and epigenetics in cancer.- MicroRNA SNPs in Cancer.- Bioinformatics Approaches to the study of microRNAs.- Beyond miRNAs: role of other non-coding RNAs in cancer.- Translational Implications for non-coding RNA in Cancer.- Index.
Summary
The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive guide on non-coding RNAs and cancer, spanning from its role as cancer biomarkers, to providing the most useful bioinformatic tools, to presenting some of the most relevant discoveries, which indicates how these fascinating molecules act as fine orchestrators of cancer biology.
