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Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In Pharmacogenomics in Drug Discovery and Development, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. Divided into three sections, the volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases.
Comprehensive and up-to-date, Pharmacogenomics in Drug Discovery and Development is an ideal volume for scientists striving to transform disease treatment into disease prevention.
List of contents
The Integration of Personalized and Systems Medicine.- Applications of Microarrays and Biochips in Pharmacogenomics.- Confounding in Genetic Association Studies and Its Solutions.- Pharmacogenetics of Membrane Transporters.- Pharmacogenomics of Drug-Metabolizing Enzymes and Drug Transporters in Chemotherapy.- Pharmacogenomics of G Protein-Coupled Receptor.- G Protein-Coupled Receptors Disrupted in Human Genetic Disease.- G Protein-Coupled Receptor Pharmacogenetics.- Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders.- Pharmacogenomics in Alzheimer's Disease.- Pharmacogenetics of Asthma.- From SNPs to Functional Studies in Cardiovascular Pharmacogenomics.- Pharmacogenomics in Gastrointestinal Disorders.- Pharmacogenomics in Rheumatoid Arthritis.- Cancer Pharmacogenetics.- Pharmacogenomics in the Preclinical Development of Vaccines.- Pharmacogenomics in the Evaluation of Efficacy and Adverse Events During Clinical Development of Vaccines.
Summary
Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field of pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In this book, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. Divided into three sections, the volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. Comprehensive and up-to-date, this book is an ideal volume for scientists striving to transform disease treatment into disease prevention.
Additional text
From the reviews:
"This volume in the Methods in Molecular Biology series covers pharmacogenomics in drug discovery. … The book is intended for scientists in academic, industrial, and health care settings who are striving to transform disease treatment into disease prevention. … The advanced technologies are presented in a very detail manner, even including step-by-step protocols. … By covering topics from individual molecules to systemic diseases … this book provides an overview of current knowledge on the use of pharmacogenomics in therapeutics of disease." (Xiaobo Zhong, Doody’s Review Service, July, 2008)
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From the reviews:
"This volume in the Methods in Molecular Biology series covers pharmacogenomics in drug discovery. ... The book is intended for scientists in academic, industrial, and health care settings who are striving to transform disease treatment into disease prevention. ... The advanced technologies are presented in a very detail manner, even including step-by-step protocols. ... By covering topics from individual molecules to systemic diseases ... this book provides an overview of current knowledge on the use of pharmacogenomics in therapeutics of disease." (Xiaobo Zhong, Doody's Review Service, July, 2008)
