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Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. The first section of the book is devoted to basic concepts of cytokine biology, especially as this relates to the practice of immunotoxicology. Chapters in this section review the ability of external influences to modify the expression, production, and activity of these molecules. The second section provides a broad understanding of the range of cytokine activity in human disease, describing methods for assessing cytokine immunotoxicity. In the third and final section of the book, the increasingly important use of cytokines as therapeutics is explored in detail. This section includes examinations into the effects of cytokines on the immune system and in treating cancer. Timely and comprehensive, Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications will serve as both a primer and a starting point for a more detailed investigation of the role these fascinating biological regulators play in human health and disease.
List of contents
to Cytokines as Targets for Immunomodulation.- Cytokine Measurement Tools for Immunotoxicology.- The Relevance of the T1/T2 Paradigm in Immunotoxicology.- Microbial Exploitation and Subversion of the Human Chemokine Network.- The Use of Cytokines in the Identification and Characterization of Chemical Allergens.- Inflammatory Cytokines and Lung Toxicity.- Cytokine Polymorphisms and Relationship to Disease.- Effects of Drugs of Abuse on Cytokine Responses.- Preclinical Approaches for the Safety Assessment of Cytokines.- Flu-Like Syndrome and Cytokines.- Cytokine-Induced Vascular Leak Syndrome.- Cytokines and Autoimmune Diseases.- Evaluation of Antibodies in Clinical Trials of Cytokines.- Cytokines and Pharmacokinetic Drug Interactions.- Evaluation of the Immunological Effects of Cytokines Administered to Patients With Cancer.- Clinical Adverse Effects of Cytokines on the Immune System.
Summary
Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. The first section of the book is devoted to basic concepts of cytokine biology, especially as this relates to the practice of immunotoxicology. Chapters in this section review the ability of external influences to modify the expression, production, and activity of these molecules. The second section provides a broad understanding of the range of cytokine activity in human disease, describing methods for assessing cytokine immunotoxicity. In the third and final section of the book, the increasingly important use of cytokines as therapeutics is explored in detail. This section includes examinations into the effects of cytokines on the immune system and in treating cancer. Timely and comprehensive, Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications will serve as both a primer and a starting point for a more detailed investigation of the role these fascinating biological regulators play in human health and disease.
Additional text
"...unique in the way it ties together several different areas of immunology in the context of the roles of cytokines within various pathophysiological conditions and therapies...a useful reference for those interested in cytokine research." -Doody's Book Review, Weighted Numberical Score: 88 - 3 Stars
"...an interesting overview of the applications and role of cytokines in human health and disease, and with large numbers of reference supplied with each chapter it is most certainly a good source of reference material for researchers in the field." -Immunology News
"This book is the latest addition to the ‘Methods in Pharmacology and Toxicology’ series … . The editors, Robert House and Jacques Descotes, are internationally renowned experts in the immunotoxicology field … . Overall, this is a useful volume, which should serve as a good reference source for toxicologists and immunologists working in the immunotoxicology and/or biopharmaceutical fields. The various chapters are concisely written and well referenced … ." (Peter Ryle, BTS Newsletter, Winter 2007)
Report
"...unique in the way it ties together several different areas of immunology in the context of the roles of cytokines within various pathophysiological conditions and therapies...a useful reference for those interested in cytokine research." -Doody's Book Review, Weighted Numberical Score: 88 - 3 Stars
"...an interesting overview of the applications and role of cytokines in human health and disease, and with large numbers of reference supplied with each chapter it is most certainly a good source of reference material for researchers in the field." -Immunology News
"This book is the latest addition to the 'Methods in Pharmacology and Toxicology' series ... . The editors, Robert House and Jacques Descotes, are internationally renowned experts in the immunotoxicology field ... . Overall, this is a useful volume, which should serve as a good reference source for toxicologists and immunologists working in the immunotoxicology and/or biopharmaceutical fields. The various chapters are concisely written and well referenced ... ." (Peter Ryle, BTS Newsletter, Winter 2007)
