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An unprecedented compilation of state-of-the-art advances in clinical research on diabetes and obesity by premier clinical scientists around the world. This volume critically reviews the limitations and strengths of today's major techniques in clinical diabetes research, and then reviews how those methods have been used to carry out cutting-edge studies of carbohydrate, lipid, and protein metabolism in the disease. In Clinical Research in Diabetes and Obesity a premier panel of internationally recognized clinical scientists offer an unprecedented compilation of state-of-the-art advances in clinical research on diabetes and obesity. This first volume, on Methods, Assessment, and Metabolic Regulation, critically reviews the limitations and strengths of today's major techniques in clinical diabetes research, and then reviews how those methods have been used to carry out cutting-edge studies of carbohydrate, lipid, and protein metabolism in the disease. The second volume, Diabetes and Obesity, builds on this information by describing how alterations in these normal processes lead to the metabolic syndromes that we associate with obesity and noninsulin-dependent diabetes mellitus.
Clinical Research in Diabetes and Obesity presents in its two wide-ranging volumes not only all of today's cutting-edge in vivo techniques, but also details approaches to elucidating the pathophysiology of these diseases, and sheds light on the latest therapeutic modalities. Its comprehensive overview of the regulation of carbohydrate, protein, and lipid metabolism in diabetic and nondiabetic humans will prove an especially valuable contribution both to clinical science and to the care of people suffering from obesity and diabetes.
List of contents
Part I: Methods in Clinical Research. Assessment of B-Cell Function in Humans: Approach and Interpretation, Steven E. Kahn. In Vivo Measurement of Insulin Sensitivity in Humans, Masafumi Matsuda and Ralph A. DeFronzo. Insulin Action in Skeletal Muscle: In Vivo Assessment, Lawrence J. Mandarino. Glucose Effectiveness, Richard N. Bergman, Ta-Chen Ni, and Marilyn Ader. Assessment of Substrate and Energy Metabolism in Vivo, Keith N. Frayn and Ian A. Macdonald. Assessment of Free Fatty Acid Metabolism, Michael D. Jensen. Assessment of Protein Metabolism in Diabetes, K. Sreekumaran Nair. Assessment Methods of Carbohydrate Metabolism in the Liver (Glycogenolysis, Gluconeogenesis, and Glycogen Synthesis), Jerry Radziuk. Part II: Effect of Hormones on Substrate Metabolism. Insulin Effects on Substrate Metabolism, William G. Blankard and John N. Clore. The Metabolic Actions of Glucagon, Alan D. Cherrington. The Effects of Glucocorticoid Hormones on Substrate Metabolism, Sean F. Dinneen. The Role of Growth Hormone, Niels Møller, Hans Ørskov, and Ole Schmitz. Interrelationships Between the Central Nervous System and Peripheral Glucose Metabolism, Patrick J. Boyle. Part III: Regulation of Metabolism in Humans: Postabsorptive and Postprandial States. Regulation of Carbohydrate Metabolism, Roy Taylor and Gerald I. Shulman. Effects of Lipids on Blood Glucose Regulation and Insulin Action, Edward W. Kraegen, David G. P. Carey, and Lesley V. Campbell. Protein Metabolism in Healthy and Diabetic Humans, Eugene J. Barrett and David A. Fryburg. Regulation of Fuel Metabolism During Exercise, Amy E. Halseth, Pietro Galassetti, and David H. Wasserman. Glucose Counterregulation, John E. Gerich. Index.
Summary
An unprecedented compilation of state-of-the-art advances in clinical research on diabetes and obesity by premier clinical scientists around the world.
Report
This book is of superb quality and does an admirable job of lucidly and succinctly conveying...exceedingly complicated and important physiological and pathophysiological concepts.. A 'must have' for those interested in metabolism and metabolism-related clinical research. Four Stars! - Doody's Health Sciences Book Review Journal
