Middleton's Allergy, 2 Vols. - Principles and Practice (Expert Consult Premium Edition - Enhanced Online Features and Print)

Boasting a worldwide reputation as the leading text in allergy and immunology, Middleton's Allergy continues its steadfast tradition of providing comprehensive coverage of state-of-the-art basic science, as well as authoritative guidance on the clinical concepts of day-to-day diagnosis and management of allergic disorders. Offering timely information that s suited for clinicians and researchers alike, Middleton s is a user-friendly and versatile source for the knowledge you need to provide optimal care to your patients!

"A valuable source of reference and pre-sifted information ...the editors are to be commending in keeping the book up-to-date and clinically valuable." Reviewed by: Imnunology News, March 2015

List of contents

Volume 1

SECTION A

Basic Sciences Underlying Allergy and

Immunology

1 Innate Immunity

2 Adaptive Immunity

3 Immunoglobulin Structure and Function

4 Immune Tolerance

5 Cytokines in Allergic Inflammation

6 Cellular Adhesion in Inflammation

7 Chemokines

8 The Complement System

9 Lipid Mediators of Hypersensitivity and Inflammation

10 Molecular Biology and Genetic Engineering

11 Signal Transduction

12 Biology of Lymphocytes

13 Antigen-Presenting Dendritic Cells

14 Biology of Mast Cells and Their Mediators

15 Biology of Basophils

16 Biology of Eosinophils

17 Biology of Neutrophils

18 Biology of Monocytes and Macrophages

19 Airway Epithelial Cells

20 Noncontractile Functions of Airway Smooth Muscle

21 Pathophysiology of Allergic Inflammation

22 Genetics and Epigenetics in Allergic Diseases and Asthma

23 Immunobiology of IgE and IgE Receptors

24 Neuronal Control of Airway Function in Allergy

25 Resolution of Allergic Inflammation

SECTION B

Aerobiology and Allergens

26 The Structure and Function of Allergens

27 Aerobiology of Outdoor Allergens

28 Indoor Allergens

29 Preparation and Standardization of Allergen Extracts

30 Air Pollution: Indoor and Outdoor

31 Particulate and Pollen Interactions

32 Effect of the Food Matrix and Processing on the Allergenic Activity of Foods

SECTION C

The Skin

33 Structure of the Skin and Cutaneous Immunology

34 Atopic Dermatitis

35 Contact Dermatitis

36 Urticaria and Angioedema

37 Hereditary Angioedema and Bradykinin- Mediated Angioedema

38 Immune Complex-Mediated Diseases

SECTION D

The Eye

39 Allergic and Immunologic Diseases of the Eye

SECTION E

Respiratory Tract

40 The Nose and Control of Nasal Airflow

41 Nasal Provocation Testing

42 Allergic and Nonallergic Rhinitis

43 Rhinosinusitis and Nasal Polyps

44 Development, Structure, and Physiology in Normal Lung and in Asthma

45 Respiratory Tract Mucosal Immunology

46 Airway Smooth Muscle Function in Asthma: Extracellular Matrix and Airway Remodeling

47 Airway Mucus and the Mucociliary System

48 Epidemiology of Asthma and Allergic Airway Diseases

49 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma

50 Asthma Pathogenesis

51 Mouse Models of Allergic Airways Disease

52 Diagnosis of Asthma in Infants and Children

53 Management of Asthma in Infants and Children

54 Diagnosis of Asthma in Adults

55 Management of Asthma in Adolescents and Adults

56 Emergency Treatment and Approach to the Patient with Acute Asthma

57 Approach to the Patient with Exercise- Induced Bronchoconstriction

58 Asthma and Allergic Diseases during Pregnancy

59 Occupational Allergy and Asthma

60 Pathology of Asthma

61 Allergic Bronchopulmonary Aspergillosis and Hypersensitivity Pneumonitis

62 Immunologic Nonasthmatic Diseases of the Lung

63 Approach to the Patient with Chronic Cough

64 Bronchial Challenge Testing

65 Lung Imaging

66 Aerosols and Aerosol Drug Delivery Systems

Volume 2

SECTION F

Gastrointestinal Tract

67 Gastrointestinal Mucosal Immunology

68 Eosinophilic Gastrointestinal Disorders

SECTION G

Systemic Disease

69 Clinical Significance of Immunoglobulin E

70 In Vivo Methods for the Study and Diagnosis of Allergy

71 Approach to the Patient with Recurrent Infections

72 Primary Immunodeficiency Diseases

73 Human Immunodeficiency Virus and Allergic Disease

74 Laboratory Tests for Allergic and Immunodeficiency Diseases

75 Eosinophilia and Eosinophil-Related Disorders

76 Mastocytosis

77 Anaphylaxis

78 Insect Allergy

79 Drug Allergy

80 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs

81 Reactions to Foods

82 Reactions to Food and Drug Additives

83 Oral Food Challenge Testing

84 Food Allergy Management

85 Adverse Reactions to Vaccine

About the author

Prof. Stephen Holgate, MRC Clinical Professor of Immunopharmacology, Division of Respiratory Cell and Molecular Biology, University of Southhampton School of Medicine. Applying basic science to the clinical interface in allergy and asthma has been the guiding principle of Prof. Stephen Holgate's career. This has involved him in environmental and genetic epidemiology, physiology, cell and molecular biology of disease processes as they occur in humans. An AAAAI member since 1986 and Fellow from 1993, Professor Holgate has been active in the field of allergy and immunology both in the United Kingdom and overseas and in 2001 received the Academy's Honorary Fellow Award. He was President of the British Society of Allergy and Clinical Immunology (BSACI) from 1990-93 and the Robert Cook Memorial Lecturer in 1995 and 2000. He received the RCP London Graham Bull Prize for research and was elected an honorary member of the Association of Physicians in UK and Ireland following the delivery of the Sir William Osler Lecture in 2003. He has been an active contributor to the Collegium Internationale Allergologicum since 1990. Professor Holgate is a member of the Infection, Inflammation and Repair Division in the School of Medicine, University of Southampton at Southampton General Hospital, UK and since 1987 has held a Medical Research Council (MRC) Clinical Professorship. He received his undergraduate medical training at Charing Cross Hospital, London and specialised in respiratory medicine and allergy. He holds Fellowships from the Royal Colleges of Physicians, Pathologists, Institute of Biology and Academy of Medical Sciences. He is a member of the Royal Commission on Environmental Pollution and has been a censor of the Royal College of Physicians. He has served on a number of Government Committees including the Sub-committee for Efficacy and Adverse Drug Reactions of the CSM (SEAR), MRC Project Grant Committee, Systems Board, Cross Board Group and most recently Councils Subcommittee on Corporate Policy and Evaluation (SCoPE), its Clinical Research Oversight Group (CROG) and is Chairman of Councils new Subcommittee on Evaluation (SOE). He has been Chairman of the UK Department of Health Committee on the Medical Effects of Air Pollution and has been appointed as Chairman of the UK Government (DEFA) Expert Panel on Air Quality Standards and Chairman of the Science Council's Science in Health Group. He has been a member of the Royal Commission of Environmental Pollution since 2002. He serves as a member of the Board of Directors for the World Allergy Organization (WAO). Professor Holgate's wwork has been recognised with a Scientific Achievement Award of the IAACI in 1994, the Rhone-Poulenc Rorer World Health Award in 1995, the King Faisal International Prize in Medicine in 1999 and Doctorates Hon Causa at University of Ferrara, Italy and Jagellonian University, Krakow, Poland in 1997 and 1999 respectively. He was elected to the Polish Academy of Arts and Science in 2001, received the Royal Society of Medicine Ellison Cliffe Medal in 2003 and the University of Ghent Gold Medal for Achievement in Clinical Science in 2004. According to the ISI Prof. Holgate was 8th most frequently cited author between 1990-2000 in the field of Biomedical Sciences in the United Kingdom and in 2002 became a member of ISI's most highly cited researcher databas.

Summary

Focusing on allergy and immunology, this book provides comprehensive coverage of basic science, as well as guidance on the clinical concepts of day-to-day diagnosis and management of allergic disorders.

Product details

• Authors: N. Franklin Adkinson, Bruce S Bochner, Bruce S. Bochner, A Wesley Burks, Dr. A. Wesley Burks, Wesley Burks, Prof. William W. Busse, N Franklin Adkinson, Professor Stephen T. Holgate, Dr. Robert F. Lemanske, Professor Robyn E. O'Hehir
• Assisted by: N. Franklin Adkinson (Editor), Bruce S Bochner (Editor), Bruce S. Bochner (Editor), A. Wesley Burks (Editor), William W Busse (Editor), William W. Busse (Editor), Stephen T Holgate (Editor), Stephen T. Holgate (Editor), Robert F. Lemanske (Editor), Robyn E O'Hehir (Editor), Robyn E. O'Hehir (Editor)
• Publisher: Saunders
• Languages: English
• Product format: Hardback
• Released: 01.12.2013
• EAN: 9780323085939
• ISBN: 978-0-323-08593-9
• No. of pages: 1896
• Dimensions: 240 mm x 295 mm x 120 mm
• Weight: 6004 g
• Illustrations: Approx. 731 illustrations (623 in full color)
• Subjects: Guides > Health; Natural sciences, medicine, IT, technology > Medicine; Natural sciences, medicine, IT, technology > Medicine > Clinical medicine