Engineering Polymer Systems for Improved Drug Delivery

Informationen zum Autor REBECCA A. BADER, PhD, is Assistant Professor in the Department of Biomedical & Chemical Engineering at Syracuse University and resident member of the Syracuse Biomaterials Institute. Combining her expertise in chemistry and materials science, Dr. Bader's current research focuses on the development of polysaccharide-based carrier systems for targeted delivery in the treatment of rheumatoid arthritis, biofilm-related diseases, cancer, and vascular diseases. DAVID A. PUTNAM, PhD, is Associate Professor in the College of Engineering at Cornell University. His research is dedicated to the rational design and synthesis of functional biomaterials to facilitate targeted and controlled drug delivery. Dr. Putnam is a Fellow of the Coulter Foundation and the American Institute for Medical and Biological Engineering, an honor bestowed upon the top 2% of biomedical engineers in the United States. Klappentext Reviews new and emerging polymer systems that improve the accuracy of drug deliveryHigh-throughput technology has dramatically increased the pace of new drug development; however, negative side effects remain a significant problem in the field, hampering our ability to bring safe and effective drugs to market. Drawing from the latest advances in pharmaceutical science and polymer engineering, this text explains the role of polymers in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of therapeutics. As a result, readers will learn how to maximize the potential of therapeutics, including those previously eliminated as viable candidates due to undesirable interactions.Engineering Polymer Systems for Improved Drug Delivery features contributions from a team of leading experts and pioneers in the field. The text begins with an exploration of the fundamentals and challenges of drug delivery, setting a solid foundation for the text's core topics:* Injectable polymeric drug delivery systems* Implantable polymeric drug delivery systems* Oral polymeric drug delivery systems* Advanced polymeric drug deliveryEach chapter covers the basics to engage novice investigators and students as well as more advanced topics to support experienced researchers. Worked examples in every chapter help readers better understand the ins and outs of designing successful polymeric drug delivery systems. There are also practice problems that challenge readers to apply their newfound knowledge.With its systematic and logical approach, Engineering Polymer Systems for Improved Drug Delivery is recommended both as a textbook for courses in pharmaceutical science and drug delivery as well as a reference for professionals in drug delivery. Zusammenfassung Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Inhaltsverzeichnis FOREWORD xi PREFACE xiii CONTRIBUTORS xv PART I INTRODUCTION 1 1 FUNDAMENTALS OF DRUG DELIVERY 3 Rebecca A. Bader 1.1 Introduction: History and Future of Drug Delivery 3 1.2 Terminology 5 1.3 Basic Pharmacokinetics 8 1.4 Basic Pharmacodynamics 12 1.5 Mass Transfer 13 1.6 Key Points 23 1.7 Homework Problems 23 2 CHALLENGES OF DRUG DELIVERY 29 Patricia R. Wardwell and Rebecca A. Bader 2.1 Introduction 29 2.2 History and Challenges of Drug Delivery 30 2.3 Physical Barriers 31 2.4 Metabolic and Chemical Concerns 39 2.5 Physical Properties of Therapeutics 42 2.6 Polymer Carriers as a Solution to Challenges 45 2.7 Key Points 50 2.8 Homework Problems 50 PART II INJECTABLE POLYMERIC DRUG DELIVERY SYSTEMS 55 3 POLYMER-DRUG CONJUGATES 57 Cris...

List of contents

FOREWORD xi
 
PREFACE xiii
 
CONTRIBUTORS xv
 
PART I INTRODUCTION 1
 
1 FUNDAMENTALS OF DRUG DELIVERY 3
Rebecca A. Bader
 
1.1 Introduction: History and Future of Drug Delivery 3
 
1.2 Terminology 5
 
1.3 Basic Pharmacokinetics 8
 
1.4 Basic Pharmacodynamics 12
 
1.5 Mass Transfer 13
 
1.6 Key Points 23
 
1.7 Homework Problems 23
 
2 CHALLENGES OF DRUG DELIVERY 29
Patricia R. Wardwell and Rebecca A. Bader
 
2.1 Introduction 29
 
2.2 History and Challenges of Drug Delivery 30
 
2.3 Physical Barriers 31
 
2.4 Metabolic and Chemical Concerns 39
 
2.5 Physical Properties of Therapeutics 42
 
2.6 Polymer Carriers as a Solution to Challenges 45
 
2.7 Key Points 50
 
2.8 Homework Problems 50
 
PART II INJECTABLE POLYMERIC DRUG DELIVERY SYSTEMS 55
 
3 POLYMER-DRUG CONJUGATES 57
Cristina Fante and Francesca Greco
 
3.1 Introduction 57
 
3.2 Historical Perspective 58
 
3.3 Polymer-Drug Conjugates: Biological Rationale 59
 
3.4 Structural Features of Polymer-Drug Conjugates 62
 
3.5 Making a Polymer-Drug Conjugate 68
 
3.6 Current Challenges and Future Perspectives 71
 
3.7 Key Points 75
 
3.8 Worked Example 76
 
3.9 Homework Problems 76
 
4 POLYMERIC MICROPARTICLES 85
Noelle K. Comolli and Colleen E. Clark
 
4.1 Introduction 85
 
4.2 The Rationale for Microparticles 86
 
4.3 Defining the Design Criteria 87
 
4.4 Polymer Selection 89
 
4.5 Microparticle Synthesis 91
 
4.6 Microparticle Characterization Methods 96
 
4.7 Drug Release from Microparticles 100
 
4.8 Microparticle Design Examples 108
 
4.9 Key Points 110
 
4.10 Worked Example 110
 
4.11 Homework Problems 111
 
5 POLYMERIC NANOPARTICLES 117
Andrew L. Vasilakes, Thomas D. Dziubla, and Paritosh P. Wattamwar
 
5.1 Introduction 117
 
5.2 PNP Design 124
 
5.3 PNP Formulation Methods and Targeting 128
 
5.4 Nanoparticle Targeting Overview 133
 
5.5 PNP Characterization 139
 
5.6 Major Clinical Achievements 147
 
5.7 Key Points 148
 
5.8 Worked Example 149
 
5.9 Homework Problems 150
 
6 BLOCK COPOLYMER MICELLES AND VESICLES FOR DRUG DELIVERY 163
James D. Robertson, Nisa Patikarnmonthon, Adrian S. Joseph, and Giuseppe Battaglia
 
6.1 Introduction 163
 
6.2 Drug Encapsulation and Release 165
 
6.3 Bioavailability and Biodistribution 166
 
6.4 Stimuli Responsiveness 170
 
6.5 The Immune System 174
 
6.6 Gene Therapy 177
 
6.7 Cancer Therapy 180
 
6.8 Conclusions 182
 
6.9 Key Points 182
 
6.10 Homework Problems 183
 
PART III IMPLANTABLE POLYMERIC DRUG DELIVERY SYSTEMS 189
 
7 IMPLANTABLE DRUG DELIVERY SYSTEMS 191
Luis Solorio, Angela Carlson, Haoyan Zhou, and Agata A. Exner
 
7.1 Introduction 191
 
7.2 Nondegradable Polymeric Implants 193
 
7.3 Biodegradable Polymeric Implants 198
 
7.4 Conclusions and Future Perspectives 215
 
7.5 Key Points 216
 
7.6 Homework Problems 216
 
8 POLYMERIC DRUG DELIVERY SYSTEMS IN TISSUE ENGINEERING 227
Matthew Skiles and James Blanchette
 
8.1 Introduction 227
 
8.2 Wound Healing as a Prototype for Adult Tissue Generation 228
 
8.3 Bioactive Factors in Tissue Engineering and Regenerative Medicine 232
 
8.4 Delivery of Growth Factors in Tissue Engineering and Regenerative Medicine 248
 
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Product details

• Authors: RA Bader, Rebecca Bader, Rebecca A Bader, Rebecca A. Bader, Rebecca A. Putnam Bader, Bader Rebecca A., David A Putnam, David A. Putnam, Putnam David A.
• Assisted by: Rebecca A. Bader (Editor), David A. Putnam (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 11.02.2014
• EAN: 9781118098479
• ISBN: 978-1-118-09847-9
• No. of pages: 496
• Subjects: Natural sciences, medicine, IT, technology > Chemistry; Chemie, Biomedizinische Technik, chemistry, Chemical Engineering, chemische Verfahrenstechnik, Biomedical engineering, Allg. Chemische Verfahrenstechnik, Biomedizintechnik, Wirkstoffformulierung, Wirkstofftransport, Drug Formulation & Delivery, Allg. Biomedizintechnik, Wirkstofffreisetzung