Regenerative Medicine Applications in Organ Transplantation

Informationen zum Autor Giuseppe Orlando, MD, PhD, Marie Curie Fellow, is an Associate Professor and a kidney and pancreas transplant surgeon scientist at the Wake Forest University School of Medicine, in Winston Salem, USA. His research aims at developing platforms for the bioengineering and regeneration of transplantable organs, and at developing therapies to enhance the innate ability of the human body to repair itself after damage. His literature output aims at bridging organ transplantation to regenerative medicine. Klappentext Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Zusammenfassung Encompasses tissue engineering! biomaterial sciences! stem cell biology! and developmental biology! all from a transplant perspective. This book intends to provide insight into the synergy between organ transplantation and regenerative medicine. It explains importance and future potential of regenerative medicine to the transplant community. Inhaltsverzeichnis Meet the Editors Preface 1. Introduction: Regenerative medicine and solid organ transplantation from a historical perspective 2. Solid organ transplantation: has the promise been kept and the needs met? Principles of Regenerative Medicine and Cell, Tissue, and Organ Bioengineering 3. Strategies for the specification of tissue engineering biomaterials 4. Principles of Stem Cell Biology 5. Principles of cell sheet technology 6. Principles of bioprinting technology 7. Synthetic biomaterial for regenerative medicine applications 8. Natural biomaterials for regenerative medicine applications 9. Bioartificial biomaterials for regenerative medicine applications 10. Bioactivated materials for cell and tissue guidance 11. Biocompatibility and immune response to biomaterials 12. Harnessing regenerative and immunomodulatory properties of stem cells 13. Bioreactors for tissue engineering purposes Kidney 14. Current status of renal transplantation 15. Living related renal transplantation: progress, pitfalls and promise 16. Machine perfusion of kidneys donated after cardiac death: the Carrel and Lindbergh legacy 17. Renal regeneration: the bioengineering approach 18. Renal regeneration: the stem cell biology approach 19. Renal regeneration: the developmental approach Liver 20. Current status of liver transplantation 21. Living related liver transplantation: progress, pitfalls and promise 22. Donation after cardiac death liver transplantation 23. Artificial liver support 24. Liver regeneration: the bioengineering approach 25. Liver regeneration: the developmental biology approach 26. Liver regeneration: the stem cell approach 27. Liver bioengineering using human cells Heart 28. Current status of heart transplantation 29. Artificial heart support 30. Heart regeneration: the bioengineering approach 31. Heart regeneration: the developmental and stem cell biology approach Small Bowel 32. Current status of intestinal transplantation 33. Living related small bowel transplantation: progress, pitfalls and promise 34. Intestinal regeneration: the bioengineerin...

List of contents

Meet the Editors
Preface
1. Introduction: Regenerative medicine and solid organ transplantation from a historical perspective
2. Solid organ transplantation: has the promise been kept and the needs met?
Principles of Regenerative Medicine and Cell, Tissue, and Organ Bioengineering
3. Strategies for the specification of tissue engineering biomaterials
4. Principles of Stem Cell Biology
5. Principles of cell sheet technology
6. Principles of bioprinting technology
7. Synthetic biomaterial for regenerative medicine applications
8. Natural biomaterials for regenerative medicine applications
9. Bioartificial biomaterials for regenerative medicine applications
10. Bioactivated materials for cell and tissue guidance
11. Biocompatibility and immune response to biomaterials
12. Harnessing regenerative and immunomodulatory properties of stem cells
13. Bioreactors for tissue engineering purposes
Kidney
14. Current status of renal transplantation
15. Living related renal transplantation: progress, pitfalls and promise
16. Machine perfusion of kidneys donated after cardiac death: the Carrel and Lindbergh legacy
17. Renal regeneration: the bioengineering approach
18. Renal regeneration: the stem cell biology approach
19. Renal regeneration: the developmental approach
Liver
20. Current status of liver transplantation
21. Living related liver transplantation: progress, pitfalls and promise
22. Donation after cardiac death liver transplantation
23. Artificial liver support
24. Liver regeneration: the bioengineering approach
25. Liver regeneration: the developmental biology approach
26. Liver regeneration: the stem cell approach
27. Liver bioengineering using human cells
Heart
28. Current status of heart transplantation
29. Artificial heart support
30. Heart regeneration: the bioengineering approach
31. Heart regeneration: the developmental and stem cell biology approach
Small Bowel
32. Current status of intestinal transplantation
33. Living related small bowel transplantation: progress, pitfalls and promise
34. Intestinal regeneration: the bioengineering approach
35. Intestinal regeneration: the developmental biology approach
36. Intestinal regeneration: stem cell approach
37. Building blocks for engineering the small intestine
Endocrine pancreas and islets of Langerhans
38. Current status of pancreas transplantation
39. Living related pancreas transplantation: progress, pitfalls and promise
40. Current status of islet transplantation
41. Pancreatic islets regeneration: the bioengineering approach
42. Pancreatic islet regeneration: the developmental and stem cell biology approach
43. Microencapsulation technology
44. Autologous islets transplantation
Lung
45. Current status of lung transplantation
46. Living related lung transplantation: progress, pitfalls and promise
47. Artificial Lung Support
48. Lung regeneration: the bioengineering approach
49. Lung regeneration: the developmental biology approach
50. Lung regeneration: stem cell approach
Composite tissues allotransplantation
Immunosuppression-free transplantation in the regenerative medicine era
Epilogue: Organ Bioengineering and Regeneration as the new Holy Grail of Organ Transplantation

Report

"It is without doubt a very valuable book that captures well the current status of the many areas it addresses...It is a superb summary of the current status of RM and organ transplantation." --Expert Review of Clinical Immunology, Regenerative Medicine Applications in Organ Transplantation
".represents an invaluable reference for students, physicians, and researchers who are interested in getting a comprehensive, up-to-date snapshot on how regenerative medicine and organ transplantation are reshaping the medical profession." --Transplantation,November 27,2014
".an invaluable reference for students, physicians, and researchers who are interested in getting a comprehensive up-to-date snapshot on how regenerative medicine and organ transplantation are reshaping the medical profession." --Transplantation, Nov 27 2014
"Given the implications that a chronic shortage of organs has on public health and society, this book is a valuable resource for students and professionals seeking to do something about this problem by taking advantage of cutting-edge developments in one of those most dynamic scientific disciplines existing today, namely regenerative medicine." --Regenerative Medicine 2014 9(3)
"The text is well organized.Chapters on tracheal reconstruction and bladder reconstruction are impressive in demonstrating proximity to clinical utility and indicate that simple structural elements can be manufactured and implanted in humans to bridge a limited defect.if you want to spark your enthusiasm for what is to come, then this textbook is a fine first step into the future." --American Journal of Transplantation, June 2014
"With beautiful illustrations throughout that greatly enhance the overall reading experience of this book, this book is a must-have for anyone interested in tissue engineering and organ transplantation. This is one of the best textbooks I have come across that combines surgery with science, and it is a must for all surgeon-scientists involved in tissue engineering and organ transplantation." --BCS Online, April 3, 2014
"This book succeeds in providing a detailed and comprehensible description of current and future therapies for solid organ replacement. It is unique in that it encompasses all solid organs and compiles a great deal of research. It will serve as a valuable reference for all those involved in the evolution of transplantation." Rating: 4 Stars --Organ Transplantation review on Doody.com, January 24, 2014

Product details

• Authors: Giuseppe Orlando, Giuseppe (EDT) Orlando
• Assisted by: Giuseppe Orlando (Editor), Giuseppe (Marie Curie Fellow Orlando (Editor), Giuseppe (Marie Curie Fellow Department of General Surgery Orlando (Editor), Giuseppe (Section of Transplantation Orlando (Editor), Orlando Giuseppe (Editor)
• Publisher: Academic Press London
• Languages: English
• Product format: Hardback
• Released: 01.09.2013
• EAN: 9780123985231
• ISBN: 978-0-12-398523-1
• No. of pages: 1200
• Series: Academic Press
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Psychiatrie, MEDICAL / Psychiatry / General, SCIENCE / Life Sciences / Biology, MEDICAL / Neuroscience, Medical / Nursing, MEDICAL / Surgery / Transplant, Transplant Surgery