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The papers assembled in this volume bring the reader to the forefront of research on the third component of complement, one of the most versatile and multifunctional molecules known to date. Unlike publications on individual characteristics, this vollume brings together all the structural and functional aspects of C3 and the C3-binding proteins, the latter including serum proteins, cell surface receptors and proteins of foreign origin. A wealth of information on the various aspects of the genetics, chemistry, biology and pathophysiology of C3 and of the 20 different proteins described to date to react with C3 is presented in numerous concise and comprehensive reviews.
List of contents
Contents: Participation of C3 and its Ligands in Complement Activation.- Biosynthesis and Genetics of C3.- Molecular Aspects of C3 Interactions and Structural/Functional Analysis of C3 from Different Species.- The Thioester Bond of C3.- Complement Receptor Type 1 (C3b/C4b Receptor; CD35) and Complement Receptor Type 2 (C3d/Epstein-Barr Virus Receptor; CD21).- The Leukocyte Cell Surface Receptor(s) for the iC3b Product of Complement.- Decay-Accelerating Factor and Membrane Cofactor Protein.- Factor H.- C3 Binding Proteins of Foreign Origin.- Structure and Function of C3a Anaphylatoxin.- Molecular Modelling of C3 and its Ligands.- C3 Deficiencies.- Structural and Functional Analysis of C3 Using Monoclonal Antibodies.- Subject Index.
