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Informationen zum Autor AKHLAQ FAROOQUI is an Adjunct Associate Professor of Medical Biochemistry at Ohio State University. He is author of over 180 peer-reviewed research articles, and author/editor of eight books and an expert in fields of glycerophospholipid metabolism, excitotoxicity, bioactive ether lipids, and phospholipases A2 in brain. TAHIRA FAROOQUI is a Research Scientist in the Department of Entomology at Ohio State University. She is the author of 40 peer-reviewed research articles and several monographs and an expert on glycerophospholipid and sphingolipid metabolism, biogenic amines, and neural plasticity. Klappentext Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome - abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension - to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders.Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians. Zusammenfassung Metabolic Syndrome and Neurological Disorders compiles data and analyses of the cluster of common pathologies to generate a complete, updated guide to the link between metabolic syndrome and neurological disorders. Inhaltsverzeichnis Foreword Mark P. Mattson xi Preface Tahira Farooqui and Akhlaq A. Farooqui xiii Acknowledgments Tahira Farooqui and Akhlaq A. Farooqui xv Contributors xvii 1 Insulin Resistance and Metabolic Failure Underlie Alzheimer Disease 1 Suzanne M. de la Monte and Ming Tong 2 Insulin Receptor and the Pathophysiology of Alzheimer Disease 31 Johanna Zemva and Markus Schubert 3 Contribution of Insulin Resistance in Pathogenesis of Alzheimer Disease 51 Adnan Erol 4 Insulin-Leptin Signaling in the Brain 75 Vicente Barrios, Emma Burgos-Ramos, and Jes¿us Argente 5 The Janus Face of Insulin in Brain 85 Ana Duarte, Emanuel Candeias, S¿onia C. Correia, Renato X. Santos, Cristina Carvalho, Susana Cardoso, Ana I. Pl¿acido, Maria S. Santos, Catarina R. Oliveira, and Paula I. Moreira 6 Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease 115 Maite Solas and Maria J. Ram¿ýrez 7 Contribution of Phospholipid, Sphingolipids, and Cholesterol-Derived Lipid Mediators in the Pathogenesis of Metabolic Syndrome and Neurological Disorders 137 Akhlaq A. Farooqui and Tahira Farooqui 8 Lipids, Cholesterol, and Oxidized Cholesterol in Alzheimer Amyloid Beta-Mediated Neurotoxicity 163 Mun'delanji C. Vestergaard, Masamune Morita, Tsutomu Hamada, and Masahiro Takagi 9 Of Sound Mind and Body: Dietary Lifestyles, Promotion of Healthy Brain Aging, and Prevention of Dementia in Healthy Individuals 179 Giulio Maria Pasinetti, Amanda Bilski, Lap Ho, Jun Wang, Mario Ferruzzi, Masahito Yamada, Kenjiro Ono, and Salvatore Mannino 10 Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction 191 Jae-Sung Lim and Hyung-Min Kwon 11 Neurochemical Linkage Among Metabolic Syndrome, Alzheimer Disease, and Depression 197
