Metals in Cells

Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs.
 
This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the "metallome"] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know.
 
The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.

List of contents

Contributors xi
 
Series Preface xix
 
Volume Preface xxi
 
PART 1: INTRODUCTION 1
 
Mechanisms Controlling the Cellular Metal Economy 3
Benjamin A. Gilston and Thomas V. O'Halloran
 
PART 2: PROBING METALS AND CROSS TALK IN THE METALLOME 15
 
The Metallome 17
Vadim N. Gladyshev and Yan Zhang
 
Cyanobacterial Models that Address Cross-Talk in Metal Homeostasis 39
Carl J. Patterson, Rafael Pernil, Andrew W. Foster and Nigel J. Robinson
 
Sparing and Salvaging Metals in Chloroplasts 51
Crysten E. Blaby-Haas and Sabeeha S. Merchant
 
Fluorescent Probes for Monovalent Copper 65
M. Thomas Morgan, Pritha Bagchi and Christoph J. Fahrni
 
Fluorescent Zinc Sensors 85
Amy E. Palmer, Jose G. Miranda and Kyle P. Carter
 
X-Ray Fluorescence Microscopy 99
James E. Penner-Hahn
 
PART 3: MOVING METALS IN CELLS 111
 
Iron and Heme Transport and Trafficking 113
Yvette Y. Yien and Barry H. Paw
 
Iron in Plants 131
Jessica B. Weng and Mary Lou Guerinot
 
Transport of Nickel and Cobalt in Prokaryotes 145
Thomas Eitinger
 
Transport Mechanism and Cellular Functions of Bacterial Cu(I)-ATPases 155
Jose M. Arguello, Teresita Padilla-Benavides and Jessica M. Collins
 
Copper Transport in Fungi 163
Simon Labbe, Jude Beaudoin and Raphael Ioannoni
 
Structural Biology of Copper Transport 175
Adrian G. Flores, Christopher R. Pope and Vinzenz M. Unger
 
Zinc Transporters and Trafficking in Yeast 183
Yi-Hsuan Wu and David J. Eide
 
Cadmium Transport in Eukaryotes 195
Nathan Smith, Wenzhong Wei and Jaekwon Lee
 
PART 4: METALS IN REGULATION 207
 
Metal Specificity of Metallosensors 209
Khadine A. Higgins and David P. Giedroc
 
Metal Homeostasis and Oxidative Stress in Bacillus subtilis 225
Zhen Ma and John D. Helmann
 
Regulation of Manganese and Iron Homeostasis in the Rhizobia and Related alpha-Proteobacteria 237
Mark R. O'Brian
 
The Iron Starvation Response in Saccharomyces cerevisiae 249
Caroline C. Philpott and Pamela M. Smith
 
Hepcidin Regulation of Iron Homeostasis 265
Clara Camaschella and Laura Silvestri
 
NikR: Mechanism and Function in Nickel Homeostasis 277
Michael D. Jones, Andrew M. Sydor and Deborah B. Zamble
 
Regulation of Copper Homeostasis in Plants 289
Marinus Pilon and Wiebke Tapken
 
Regulation of Zinc Transport 301
Taiho Kambe
 
Selenoproteins--Regulation 311
Lucia A. Seale and Marla J. Berry
 
PART 5: METALS IN CELLULAR DAMAGE AND DISEASE 321
 
Metals in Bacterial Pathogenicity and Immunity 323
Jennifer S. Cavet
 
Manganese in Neurodegeneration 335
Daiana Silva Avila, Robson Luiz Puntel, Felix Antunes Soares, Joao Batista Teixeira da Rocha and Michael Aschner
 
Iron Sequestration in Immunity 349
Colin Correnti and Roland K. Strong
 
Molecular Basis of Hemochromatosis 361
Paul J. Schmidt
 
Copper in Brain and Neurodegeneration 373
Jeffrey R. Liddell, Ashley I. Bush and Anthony R. White
 
Copper Transporting ATPases in Mammalian Cells 395
Nan Yang and Svetlana Lutsenko
 
Copper in Immune Cells 409
Karrera Y. Djoko, Maud E.S. Achard and Alastair G. McEwan
 
Selenoenzymes and Selenium Trafficking: An Emerging Target for Therapeutics 421
William Self and Sarah Rosario
 
Resistance Pathways for Metalloids and Toxic Metals 429
Zijuan Liu, Christopher Rensing and Barry P. Rosen
 
PART 6: COFACTOR ASSEMBLY 443
 
Fe-S Cluster Biogenesis in Archaea and Bacteria 445
Harsimranjit K. Chahal, Jeff M. Boyd and F. Wayne Outten
 
Mitochondrial Iron Metabolism and the Synthesis of Iron-Su

About the author

Prof. Robert A. Scott (Editor-in-Chief Encyclopedia of Inorganic and Bioinorganic Chemistry)
Distinguished Research Professor, University of Georgia, USA.
Prof. Valeria Culotta, Biochemistry and Molecular Biology Department, Joint Departmental Affiliations Environmental Health Sciences
Research in the Culotta lab focuses on the role of metal ions and oxygen radicals in biology and disease. Metal ions such as copper, iron and manganese are not only trace nutrients but can be quite toxic. One mechanism of toxicity is through generation of reactive oxygen species (ROS) that have been implicated in numerous human disorders from neurodegeneration to cancer to aging. Through molecular genetic approaches and high through-put genetic screens in yeast, we have identified a number genes and pathways that are involved in transition metal and reactive oxygen metabolism. Virtually all are well conserved throughout eukaryotes including humans. Our laboratory uses a combination of yeast, C. elegans and cell culture systems at the crossroads of bioinorganic chemistry, cell biology and molecular genetics.

Summary

Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs.

Product details

• Authors: V Culotta, Valeria Culotta, Valeria (Johns Hopkins University Culotta, Valeria Scott Culotta
• Assisted by: Valeri Culotta (Editor), Valeria Culotta (Editor), Culotta Valeria (Editor), Robert A. Scott (Editor), Scott Robert A. (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 27.09.2013
• EAN: 9781119953234
• ISBN: 978-1-119-95323-4
• No. of pages: 608
• Series: EIC Books; EIC Books
• Subjects: Natural sciences, medicine, IT, technology > Chemistry; Chemie, biochemistry, chemistry, Enzyme u. Rezeptoren, Enzymes & Receptors, Bioanorganische Chemie, Chemical biology, Bioinorganic Chemistry