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The first volume of the series entitled Comprehensive Virology was pub lished in 1974 and the last is yet to appear. We noted in 1974 that virology as a discipline has passed through its descriptive and phenomenological phases and was joining the molecular biology revolution. The volumes published to date were meant to serve as an in-depth analysis and standard reference of the evolving field of virology. We felt that viruses as biological entities had to be considered in the context of the broader fields of mo lecular and cellular biology. In fact, we felt then, and feel even more strongly now, that viruses, being simpler biological models, could serve as valuable probes for investigating the biology of the far more complex host cell. During the decade-long compilation of a series of books like Comprehensive Virology, some of the coverage will obviously not remain up-to-date. The usual remedy to this aspect of science publishing is to produce a second edition. However, in view of the enormous increase in knowledge about viruses, we felt that a new approach was needed in covering virology in the 1980s and 1990s. Thus we decided to abandon the somewhat arbitrary subgrouping of the subject matter of Compre hensive Virology under the titles Reproduction, Structure and Assembly, Regulation and Genetics, Additional Topics, and Virus-Host Interac tions. Instead we have organized a new series entitled The Viruses.
List of contents
1 The Biology of Cytomegaloviruses.- I. Properties of Cytomegaloviruses.- II. In Vitro Infection of Host Cells.- III. Pathogenesis in Natural Hosts.- V. Latency, Persistence, and Reactivation.- VI. Cell Transformation by Cytomegaloviruses.- VII. Control of Cytomegalovirus Infections.- References.- 2 Molecular Biology of Cytomegaloviruses.- I. Introduction.- II. Rate of Infectious Virus Production: Comparisons between Herpes Simplex Virus and Cytomegalovirus.- III. Viral Genome.- IV. Transcription of the Viral Genome.- V. Virus-Induced Protein and Glycoprotein Synthesis in Infected Cells.- VI. Virus-Induced Enzymes.- VII. Viral DNA Replication.- VIII. Virions and Dense Bodies of Cytomegalovirus.- IX. Nonproductive Infection.- X. Conclusion.- References.- 3 Molecular Biology of Varicella-Zoster Virus.- I. Introduction.- II. In Vitro Growth Problem.- III. Varicella-Zoster-Virus-Related Proteins.- IV. Varicella-Zoster Virus DNA.- V. Conclusions.- References.- 4 Bovine Herpesviruses.- I. Introduction.- II. History.- III. Classification.- IV. Morphology and Morphogenesis.- V. Genetic Material.- VI. Proteins and Antigens.- VII. Properties of the Viruses.- VIII Immune Response and Other Defense Mechanisms.- IX. Diseases, Experimental Infections, and Pathology.- X. Pathogenesis.- XI. Diagnosis.- XII. Epidemiology.- XIII. Concluding Remarks.- References.- 5 The Equine Herpesviruses.- I. Introduction.- II. Classification and Clinical Features.- III. Structure and Molecular Anatomy of Equine Herpesvirus Virions and Their Components.- IV. Replication.- V. Defective Interfering Particles and Systems of Persistent Infection.- VI. Oncogenic Potential of Equine Herpesviruses.- VII. Evolutionary Relationships.- VIII. Antiviral Prospects.- References.- 6 Biology and Properties ofFish and Reptilian Herpesviruses.- I. Introduction.- II. Reptilian Herpesviruses.- III. Teleost Fish Herpesviruses.- References.- 7 Amphibian Herpesviruses.- I. Introduction.- II. Lucké Tumor.- III. Lucké Tumor Herpesvirus.- IV. Frog Virus 4.- V. Conclusions.- References.- 8 B Virus (Herpesvirus simiae).- I. Introduction and History.- II. Morphogenesis and Morphology.- III. Genetic Material.- IV. Antigens and Proteins.- V. Serology.- VI. Pathogenesis and Pathology.- VII. Epidemiology.- VIII. Conclusions.- References.
