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The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having only recently passed through its descriptive phase of naming and num bering, has probably reached that stage at which relatively few new truly new-viruses will be discovered. Triggered by the intellectual probes and techniq ues of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have so far been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 22 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed and scattered throughout a wide literature. I n this way, we hope to place the entire field in perspective as well as to develop an invaluable reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere but which also provides a logical progression of developing facts and integrated concepts.
List of contents
1 Parvovirus Reproduction.- 1. Introduction.- 2. Biological Properties.- 3. Properties and Components of Virions.- 4. Multiplication of Nondefective Parvoviruses.- 5. Multiplication of Defective Parvoviruses.- 6. Conclusions.- 7. References.- 2 Reproduction of Papovaviruses.- 1. General Properties of Papovaviruses.- 2. DNA Replication.- 3. Transcription of SV40 and Polyoma DNA.- 4. The Proteins of SV40 and Polyoma.- 5. Other Properties of Papovaviruses.- 6. References.- 3 Reproduction of Adenoviruses.- 1. Introduction.- 2. Architecture and Composition of the Virion.- 3. Biochemistry of the Structural Proteins of Adenovirus.- 4. The Adenovirus Genome.- 5. Classification of Adenoviruses.- 6. The Productive Infection.- 7. Abortive Infections.- 8. Cell Transformation.- 9. Adenovirus Genetics.- 10. Conclusions and Prospects for the Future.- 11. References.- 4 The Replication of Herpesviruses.- 1. Objectives and Scope.- 2. The Herpesvirion.- 3. Biosynthesis of the Virus in Permissive Cells.- 4. Alterations of Cellular Function and Structure During Productive Infection.- 5. References.- 5 Reproduction of Poxviruses.- 1. Introduction.- 2. Subgroups.- 3. Virions.- 4. Growth Cycle.- 5. Effects on Host Cell Metabolism.- 6. Interference with Poxvirus Replication.- 7. Summary.- 8. References.- Addendum to Chapter 2.
