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In this volume, a distinguished international group of contributors present the latest molecular, organismal, and epidemiological research on arenaviruses. Their work will broaden both the clinician's and the researcher's knowledge of basic mechanisms of immunological tolerance, viral immunosuppression, the nature of protective immune responses to vaccination, and viral effects on cell functions.
List of contents
I. Molecular Structure of the Arenaviruses.- 1 Arenavirus Ultrastructure and Morphogenesis.- 2 Glycoproteins of the Arenaviruses.- 3 Antigenic Diversity among the Arenaviruses.- 4 Genetic Organization of Junin Virus, the Etiological Agent of Argentine Hemorrhagic Fever.- 5 Genetic Variation in Junin Virus.- 6 The Unusual Mechanism of Arenavirus RNA Synthesis.- 7 Subgenomic RNAs of Tacaribe Virus.- 8 Molecular Biology of the Prototype Arenavirus, Lymphocytic Choriomeningitis Virus.- 9 Arenavirus Replication: Molecular Dissection of the Role of Viral Protein and RNA.- 10 Molecular Phylogeny of the Arenaviruses and Guide to Published Sequence Data.- II. Immunopathology, Vaccines, and Epidemiology.- 11 Lymphocytic Choriomeningitis Virus: History of the Gold Standard for Viral Immunobiology.- 12 Influence of Host Genes on the Outcome of Murine Lymphocytic Choriomeningitis Virus Infection: A Model for Studying Genetic Control of Virus-Specific Immune Responses.- 13 Molecular Anatomy of the Cytotoxic T-Lymphocyte Responses to Lymphocytic Choriomeningitis Virus.- 14 Virus-Induced Acquired Immunosuppression by T-Cell-Mediated Immunopathology and Vaccine Strategies.- 15 Construction and Evaluation of Recombinant Virus Vaccines for Lassa Fever.- 16 The Tacaribe Complex: The Close Relationship between a Pathogenic (Junin) and a Nonpathogenic (Tacaribe) Arenavirus.- 17 Arenavirus Pathophysiology.- 18 Lassa Virus and Central Nervous System Diseases.- 19 Ecology and Epidemiology of Arenaviruses and Their Hosts.
