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Corona- and related viruses are important human and animal pathogens that also serve as models for other viral-mediated diseases. Interest in these pathogens has grown tremendously since the First International Symposium was held at the Institute of Virology and Immunobiology of the University of Wiirzburg, Germany. The Sixth International Symposium was held in Quebec City from August 27 to September I, 1994, and provided further understanding of the molecular biology, immunology, and pathogenesis of corona-, toro-, and arterivirus infections. Lectures were given on the molecular biology, pathogenesis, immune responses, and development of vaccines. Studies on the pathogenesis of coronavirus infections have been focused mainly on murine coronavirus, and mouse hepatitis virus. Neurotropic strains ofMHV (e.g., JHM, A59) cause a demyelinating disease that has served as an animal model for human multiple sclerosis. Dr. Samuel Dales, of the University of Western Ontario, London, Canada, gavea state-of-the-art lecture on our current under standing of the pathogenesis of JHM-induced disease.
List of contents
Genetic Resistance to Coronavirus Infection; E. Buschman, E. Skamene Factors Controlling Coronavirus Infections and Disease of the Central Nervous System: A Review; S. Dales Characterization of the S Protein of Enterotropic Murine Coronavirus StrainY; S. R. Compton, S. Kunita Biological and Molecular Differentiation between Coronaviruses Associated with Neonatal Calf Diarrhea and Winter Dysentery in Adult Cattle; G. Millane, et al. Molecular Differentiation of Transmissible Gastroenteritis Virus and Porcine Respiratory Coronavirus Strains: Correlation with Antigenicity and Pathogenicity; D.J. Jackwood, et al. Organ Specific Endothelial Cell Heterogeneity Influences Differential Replication and Cytopathogenicity of MHV3 and MHV4: Implications in Viral Tropism; J. Joseph, et al. Genomic Regions Associated with Neurotropism Identified in MHV by RNARNA Recombination; E. Lavi, et al. Involvement of Microtubules and the Microtubuleassociated Protein Tau in Trafficking of JHM Virus and Components within Neurons; K. Kalicharran, S. Dales Evolution and Persistence Mechanisms of Mouse Hepatitis Virus; W. Chen, R.S. Baric Spread of MHVJHM from Nasal Cavity to White Matter of Spinal Cord: Transneuronal Movement and Involvement of Astrocytes; S. Perlman, et al. 84 additional articles. Index.
Summary
Proceedings of the Sixth International Symposium held in Quebec City, Canada, August 27-September 1, 1994.
