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From the tissue culture dish to genetically modified mice, this volume explores the long recognized role of steroid hormones in regulating cell proliferation and differentiation. Many striking effects of steroid hormones are apparent during development and neoplasia and these topics are covered extensively. Several chapters address the pharmacological uses of steroid and related hormones, their analogs and antagonists in controlling growth of endocrine cancers. This book also highlights the complex role of cross talk between steroid hormones and signals initiated at the cell surface in the regulation of cell cycle in hormone responsive tissues.
List of contents
1. Mechanisms of Steroid Receptor and Growth Factor Cross Talk.- 2. Regulation of G1 to S Phase Transition by Adhesion and Growth Factor Signaling.- 3. Control of Mammary Epithelial Cell Proliferation: The Unique Role of the Progesterone Receptor.- 4. Estrogen/Estrogen Antagonist Regulation of the Cell Cycle in Breast Cancer Cells.- 5. Prostate Gland Development and Estrogenic Imprinting.- 6. Androgen Mediated Regulation of the G1-S Transition in Prostate Cancer.- 7. Steroid Hormone and Growth Factor Interaction in the Regualtion of Cell Cycle Progression.- 8. Glucocorticoid Regulation of Cell Proliferation.- 9. Vitamin D Regulation of Cell Cycle and Differentiation in Myeloid Cells.- 10. Antiproliferative Effect of Vitamin D in Prostate Epithelial Cells.- 11. Regulation of the Cell Cycle by Peroxisome Proliferator-Activated Recceptor Gamma (PPAR?).- 12. Regulation of Glucocorticoid Receptor Function During the Cell Cycle.- 13. Interaction of Cell Cycle Regulatory Proteins with the Androgen Receptor.- 14. Cyclin Dependent Kinase Regulation of Estrogen Receptor Phosphorylation and Transcriptional Activation.
Summary
From the tissue culture dish to genetically modified mice, this volume explores the long recognized role of steroid hormones in regulating cell proliferation and differentiation. Many striking effects of steroid hormones are apparent during development and neoplasia and these topics are covered extensively. Several chapters address the pharmacological uses of steroid and related hormones, their analogs and antagonists in controlling growth of endocrine cancers. This book also highlights the complex role of cross talk between steroid hormones and signals initiated at the cell surface in the regulation of cell cycle in hormone responsive tissues.
