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The International Brain Hypothermia Symposium 2004was the second time I have had the honor of opening such a gathering on brain hypothermia treatment. It was a great pleasure to greet the participants in the hope that their valuablecontributions would make the Tokyo meeting memorable. Brainhypothermia has long been seen as a promising method that may overcome current limitations on brain resuscitation in patients with severe brain damage. However, although excellentresults have been obtained in experimental animal models, for some reason brain hypothermia has not alwaysbeen successful clinically,and resolving this problem has been a major challenge facing physicians specializing in brain therapies. The ICUmanagement of recent research has uncovered newmechanisms ofbrain damage not seen in animal models, including brain thermo-pooling at temperatures above 40°C in severe brain damage, masking neuronal hypoxia even with normal cerebral blood flow. Stress-related hyper glycemia with brain hypothermia was expected to generate useful results in patients with external injuries, cerebral occlusive stroke, and cardiac arrest. In recent clinical studies of brain hypothermia treatment, many excellent results began being reported on the manage ment of severe brain injury, ischemic stroke, and post-resuscitation after cardiac arrest. However, in clinical brain hypothermia treatment many questions remained about appro priate treatment targets, leu management technique, prevention of complications, control of brain tissue temperature,management of hypothermia insult,and mechanisms underly ing the onset of vegetative states.
List of contents
1. Opening the Door to Hypothermia.- 2. Up-to-date Basic Science of Hypothermia.- 3. Development of Brain Hypothermia Treatment.- 4. Technique and ICU Management of Brain Hypothermia.- 5. Hypothermia Response.- 6. Neonate and Pediatric Brain Hypothermia.- 7. Experimental Research and Clinical Management.- 8. Preventing Persistent Vegetation.- 347.
About the author
Nariyuki Hayashi
Professor and Chairman, Department of Emergency and Critical Care Medicine, Nihon University School of Medicine
Ross Bullock
Department of Neurosurgery, Virginia Commonwealth University Health System, USA
Dalton W. Dietrich
Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami School of Medicine, USA
Tsuyoshi Maekawa
Department of Emergency and Critical Care Medicine, Yamaguchi University Hospital, Japan
Akira Tamura
Teikyo University School of Medicine, Japan
Summary
The International Brain Hypothermia Symposium 2004, held in Tokyo, was a forum for many of the world’s leading researchers and clinicians to present and discuss developments on the cutting edge of this most promising of neurological therapies. With a view to sharing this knowledge and encouraging the spread of new techniques, the editors have compiled these proceedings covering the latest technology and methods. Topics include brain thermo-pooling, hemoglobin-dysfunction-associated neuronal hypoxia, intensive care management of brain hypothermia for severely brain-injured patients, new findings not yet recorded in animal models, and control of hypothermia-associated immune crises. Also included are advanced clinical results from trauma, stroke, and cardiac arrest patients. The result is a volume that will be a valuable resource for professionals in the fields of emergency treatment, critical medicine, and neurosurgery.
