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Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels.
The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.
List of contents
1. Introduction and Overview.- 2. Immunity of Allograft Rejection: An Overview.- 3. MHC: Structure and Function.- 4. HLA Immunogenetics and Transplantation.- 5. Extracellular Processing of MHC Class I Antigens.- 6. Genetics of CD1 Molecules.- 7. Minor Histocompatibility Antigens: Molecular Barriers for Successful Tissue Transplantation.- 8. Mechanisms of AUorecognition.- 9. Complement System in AUorecognition and Rejection of Organ Transplants.- 10. Xenotransplantation.- 11. Conceptual Models in Immunity/Tolerance: Application to Transplantation.- 12. Dendritic Cells in Transplantation: Origin, Immune Activation, and Allograft Tolerance.- 13. Monocytes and Macrophages in Transplantation.- 14. Role of B Lymphocytes and Alloantibodies in Organ Transplantation.- 15. Overview of T-Cell Phenotype and Function.- 16. Costimulatory Molecules in T-Cell Activation and Transplantation.- 17. Regulatory T Cells: Professional Suppressor Cells.- 18. Cytotoxic T Lymphocytes: Mechanism of Action and Role in Allograft Rejection.- 19. Natural Killer Cells in Transplantation: Friends or Foes?.- 20. Natural Killer T (NKT) Cells in Transplantation.- 21. Immunologic Tolerance as Taught by Allografts.- 22. The Immunobiology of Post-Transplant Lymphoproliferative Disorders (PTLD).- 23. Overview of Cytokine Structure and Function.- 24. Chemokines and Transplantation.- 25. Interaction of Innate and Acquired Immune Response: Toll Receptors-Potential Link of Infection to Rejection.- 26. Nitric Oxide, Oxygen Radicals.- 27. The Role of Neutrophils in Transplantation.- 28. Heme Oxygenase-1 and Transplantation.- 29. The Heat Shock Response and Transplantation Immunology.- 30. The Role of Ischemia Reperfusion Injury in Graft Rejection.- 31. Extracellular Matrix and Organ Transplantation.- 32.Endothelial Cell Biology: Inflammatory Biomarkers and Risk of Transplant Atherosclerosis.- 33. Epithelial Cell Biology in Organ Transplantation.- 34. T Cell-Epithelial Cell Interactions in Organ Allograft Rejection.
Summary
Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels.
The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.
