Dopamine in the CNS II

Dopamine was initially regarded as a mere precursor of noradrenaline, but has progressively gained its present status of a common target for major drug classes and a substrate for some basic functions and dysfunctions of the Central Nervous System. The scientific interest has shifted from typically motor areas of the striatum to traditionally limbic ones as the nucleus accumbens and its afferent areas, the prefrontal cortex, the hippocampal formation and the basolateral amygdala. This double volume provides a systematic account of the anatomy, physiology, neurochemistry, molecular biology and behavioural pharmacology of dopamine in the CNS. The second volume deals with functional and behavioural aspects as the electrophysiology of dopamine neurons and of dopamine actions, the interaction with other transmitters and its role in behaviour and in the action of centrally acting drugs.

List of contents

13 Electrophysiological Pharmacology of Mesencephalic Dopaminergic Neurons.- 14 Presynaptic Regulation of Dopamine Release.- 15 Dopamine - Acetylcholine Interactions.- 16 Dopamine - Glutamate Interactions.- 17 Dopamine - Adenosine Interactions.- 18 Dopamine - GABA Interactions.- 19 Dopamine - Its Role in Behaviour and Cognition in Experimental Animals and Humans.- 20 Molecular Knockout Approach to the Study of Brain Dopamine Function.- 21 Behavioural Pharmacology of Dopamine D2 and D3 Receptors: Use of the Knock-out Mice Approach.- 22 Dopamine and Reward.- 23 Molecular and Cellular Events Regulating Dopamine Neuron Survival.- 24 Dopamine and Depression.- 25 Dopamine in Schizophrenia Dysfunctional Information Processing in Basal Ganglia - Thalamocortical Split Circuits.- 26 Atypical Antipsychotics.- 27 Sleep and Wake Cycle.

Summary

This double volume provides a systematic account of the anatomy, physiology, neurochemistry, molecular biology and behavioural pharmacology of dopamine in the CNS. HEP 154/II deals with functional and behavioural aspects as the electrophysiology of dopamine neurons and of dopamine actions, the interaction w. other transmitters and its role in behaviour and in the action of centrally acting drugs.

Product details

• Assisted by: Gaetano Di Chiara (Editor), Gaetan Di Chiara (Editor), Gaetano Di Chiara (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 14.10.2010
• EAN: 9783642076596
• ISBN: 978-3-642-07659-6
• No. of pages: 514
• Illustrations: XXIV, 514 p. 50 illus., 2 illus. in color.
• Series: Handbook of Experimental Pharmacology; Handbook of Experimental Pharmacology / Dopamine in the CNS; Handbook of Experimental Pharmacology; Handbook of Experimental Pharmacology / Dopamine in the CNS
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Biochemie, C, Neurowissenschaften, Zellbiologie (Zytologie), Pharmakologie, Life Sciences, Neurology, PHYSIOLOGY, Neuroscience, biochemistry, Neurosciences, Pharmacology, Biomedical and Life Sciences, Cellular biology (cytology), Biochemistry, general, Cell Biology, Pharmacology/Toxicology, neurons