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Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21-23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed.
List of contents
Dynamic Regulation of Progesterone Receptor Activity in Female Reproductive Tissues.- Steroid Receptor Coactivator 2: An Essential Coregulator of Progestin-Induced Uterine and Mammary Morphogenesis.- Inhibition of Mammary Tumorigenesis by Estrogen and Progesterone in Genetically Engineered Mice.- Estrogens, Progestins, and Risk of Breast Cancer.- Mammary Development, Carcinomas and Progesterone: Role of Wnt Signalling.- Progesterone Signaling in Mammary Gland Development.- Progesterone Receptor Isoforms in Normal and Malignant Breast.- In Vivo Characterization of Progestins with Reduced Non-genomic Activity In Vitro.- In Vitro and In Vivo Characterization of a Novel Nonsteroidal, Species-Specific Progesterone Receptor Modulator, PRA-910.
Summary
Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21–23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed.
Additional text
From the reviews:
"This book examines different aspects of progestin biology in the mammary gland, discussing both basic science and clinically relevant topics. The chapters are based on an international symposium that took place in Berlin in 2007. … The authors are all experts in their respective fields. … This exciting collection of chapters on important areas in progestin biology would be most interesting for researchers (and potentially clinicians) … . A number of novel research findings are discussed, as well as their potential applications." (Ronald N Cohen, Doody’s Review Service, August, 2008)
Report
From the reviews:
"This book examines different aspects of progestin biology in the mammary gland, discussing both basic science and clinically relevant topics. The chapters are based on an international symposium that took place in Berlin in 2007. ... The authors are all experts in their respective fields. ... This exciting collection of chapters on important areas in progestin biology would be most interesting for researchers (and potentially clinicians) ... . A number of novel research findings are discussed, as well as their potential applications." (Ronald N Cohen, Doody's Review Service, August, 2008)
