Protein Degradation in Health and Disease

Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

List of contents

Roles of SCF and VHL Ubiquitin Ligases in Regulation of Cell Growth.- Aging of Proteins and the Proteasome.- Protein Degradation in the Aging Organism.- Protein Degradation in Alzheimer's Disease and Aging of the Brain.- Protein Degradation in Human Disease.- The 26S Proteasome.- Proteasome Inhibitors.

Summary

Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Product details

• Assisted by: Michel Reboud-Ravaux (Editor), Michele Reboud-Ravaux (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 08.03.2013
• EAN: 9783642627149
• ISBN: 978-3-642-62714-9
• No. of pages: 130
• Illustrations: X, 130 p.
• Series: Progress in Molecular and Subcellular Biology; Progress in Molecular and Subcellular Biology
• Subjects: Natural sciences, medicine, IT, technology > Biology > Microbiology; Biochemie, Onkologie, Protein, C, Life Sciences, Regulation, Pathology, METABOLISM, biochemistry, Oncology, Proliferation, proteins, Biomedical and Life Sciences, Cancer Research, Biochemistry, general, Biomedical Research, Cell Biology, Cancer Biology