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Colorectal cancer is one of the most frequent human tumors. Despite tremendous advances in our knowledge about the pathogenesis of the disease, the prognosis remains poor for almost half of the individuals affected. This volume provides an updated and comprehensive description of the most relevant features of colorectal cancer - from molecular biology to prevention, from hereditary syndromes to new treatment modalities. It represents an invaluable source for clinicians who deal with colorectal neoplasms and for all those who wish to increase their knowledge of these malignancies.
List of contents
1 The Causes of Colorectal Cancer.- Descriptive Epidemiology and Temporal Trends.- The Environment and Colorectal Cancer.- Colorectal Polyps and the Adenoma-Carcinoma Sequence.- Familial and Hereditary Factors.- Gene-Environment Interactions.- Conclusions.- References.- 2 Pathogenesis of Colorectal Cancer.- Main Causes of Colorectal Cancer.- Pathogenesis of Colorectal Cancer: Different Molecular Pathways for One Disease.- Conclusions.- References.- 3 Pathology of Colorectal Cancer.- The Colorectal Mucosa.- Aberrant Crypts.- Adenomatous Polyps.- Other Types of Polyps.- Colorectal Carcinoma.- Conclusions.- References.- 4 Diagnosis and Clinical Features of Colorectal Cancer.- Clinical Findings: Symptoms and Signs.- Diagnosis of Colorectal Cancer: Old Methods and Recent Imaging Techniques.- Conclusions.- References.- 5 Colorectal Cancer Screening and Surveillance.- Colorectal Cancer Screening in the General Population.- New Screening Procedures Based on Molecular Analysis.- Screening in Individuals with Familial Colorectal Cancer.- Surveillance After Endoscopic Polypectomy.- Surveillance After Surgery for Colorectal Cancer.- Surveillance in Patients with Inflammatory Bowel Disease.- Surveillance in Hereditary Cancer Syndromes.- Conclusion: Media, Society and Colorectal Cancer Screening.- References.- 6 Prevention and Chemoprevention of Colorectal Neoplasms.- Can We Prevent Colorectal Cancer with an Appropriate Diet?.- Can We Prevent Colorectal Cancer by Modifying Our Lifestyle?.- Secondary Prevention: Is the Removal of Adenomas Effective?.- Colorectal Cancer Prevention Under Special Conditions.- Chemoprevention of Colorectal Cancer.- Conclusions.- References.- 7 Treatment of Colorectal Cancer.- Staging Colorectal Neoplasms.- Treatment of Resectable Colorectal Tumors.- Treatment of Advanced Colorectal Tumors.- Innovative Treatments for Colorectal Cancer.- Conclusions.- References.- 8 Survival and Follow-up of Colorectal Cancer.- Factors Influencing Colorectal Cancer Survival.- Temporal Trends and Ethnic Differences in Colorectal Cancer Survival.- Follow-up of Colorectal Cancer Patients.- Conclusions.- References.- 9 Cancer of the Anal Canal.- Epidemiology of Anal Cancer.- Clinical Features and Pathology.- Treatment of Cancer of the Anus.- Conclusions.- References.- 10 Hereditary Non-polyposis Colorectal Cancer (Lynch Syndrome).- Brief History of HNPCC.- Epidemiology and Frequency of Lynch Syndrome.- Formal Genetics and the Role of Family History.- Clinical Features of HNPCC.- Pathology of HNPCC.- Molecular Biology of HNPCC.- Diagnosis of HNPCC.- Genetic Counseling in HNPCC.- Management and Survival.- Conclusions.- References.- 11 Familial Adenomatous Polyposis.- Definition and Historical Overview.- Epidemiology and Formal Genetics.- Diagnosis, Clinical Features and Morphology.- Molecular Biology of FAP.- Management of Familial Adenomatous Polyposis.- Conclusions.- References.- 12 Other Polyposis of the Large Bowel.- Peutz-Jeghers Syndrome.- Juvenile Polyposis.- Cowden's Disease.- Turcot Syndrome.- Muir-Torre Syndrome and Other Rare Polyposis.- Bannayan-Riley-Ruvalcaba Syndrome.- Conclusions.- References.- 13 Carcinoid Tumors of the Large Bowel.- Brief History.- Biology and Pathology of CT.- Clinical Features of Colorectal CT.- Diagnosis and Treatment of CT of the Large Bowel.- Conclusions.- References.- 14 Colorectal Cancer at the Beginning of the New Millennium.- The Colorectal Cancer Epidemic.- Gene-Environment Interaction.- Dealing with Colorectal Cancer Patients in the "Molecular Era".- References.
Summary
Colorectal cancer is one of the most frequent human tumors. Despite tremendous advances in our knowledge about the pathogenesis of the disease, the prognosis remains poor for almost half of the individuals affected. This volume provides an updated and comprehensive description of the most relevant features of colorectal cancer - from molecular biology to prevention, from hereditary syndromes to new treatment modalities. It represents an invaluable source for clinicians who deal with colorectal neoplasms and for all those who wish to increase their knowledge of these malignancies.
