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Informationen zum Autor Rodney Ho is a Milo Gibaldi Endowed Professor at the University of Washington School of Pharmacy in Seattle. He is founder and principal scientist of Impel NeuroPharma and Nova Theranostics, as well as a visiting professor at the School of Chemical Biology and Biotechnology at Peking University. Dr. Ho co-edited the first edition of "Biotechnology and Biopharmaceuticals", and has served in an editorial capacity for?numerous journals including J. of Pharmaceutical Sciences, Frontiers in Biosciences, and Open Journal: Clinical Medicine: Blood Disorders. Klappentext The essential single source on drug discovery and biotechnology products-newly revised and updated Since the first edition of Biotechnology and Biopharmaceuticals was published, biotechnology has continued to drive therapeutic product development. The majority of new medicines coming on the market today are developed based on tools created by biotechnology-and healthcare providers who are concerned with optimum drug therapy need to understand the principles underlying the discovery, development, and application of these biological drugs and therapies of the future. Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics, and cost-effectiveness considerations. It provides research pharmacologists, biopharmaceutical R&D personnel, toxicologists, and biotechnologists with cutting-edge research on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development, including cancer vaccines, stem cell therapeutics, and cell-based therapies. Presented in three parts, and containing several appendices, Biotechnology and Biopharmaceuticals: Integrates information from pharmacology, biotechnology, and the medical sciences Covers the science and art of transforming proteins and genes into drugs Offers new coverage of cell-based therapeutics, including stem cells and immune cell therapy Highlights the unique applications of biologics, proteins, and macromolecules as therapeutics Includes new chapters on the clinical trial and approval process of individualized medicine Discusses the future direction of the field Ideal for research pharmacologists, biopharmaceutical R&D personnel, toxicologists, and biotechnologists, Biotechnology and Biopharmaceuticals will also appeal to clinical pharmacologists, pharmacists, physicians, and health scientists Zusammenfassung The essential single source on drug discovery and biotechnology products, Biotechnology and Biopharmaceuticals addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics, and cost-effectiveness considerations. Inhaltsverzeichnis Contributors xiii Foreword xv Preface xvii Preface to the First Edition xix Acknowledgments xxi Organization of the Book xxiii User Agreement xxv Part I Transforming Proteins and Genes into Drugs-The Science and the Art 1 1 Introduction to Biopharmaceuticals 3 Abstract 3 1.1 Background and Significance 4 1.2 Translation of Biotechnology for Developing Biopharmaceuticals 7 1.3 Historical Perspective of Pharmaceutical Biotechnology 8 1.4 Distinctions between Chemical Drugs Versus Biopharmaceuticals 8 1.5 Summary 10 2 Distinctions of Biologic Versus Small Molecule Platforms in Drug Development 13 Abstract 13 2.1 Introduction 14 2.2 Transforming New Molecules into Drugs: The Drug Development Process 14 2.3 Key Differences...
