Comprehensive Enantioselective Organocatalysis, 3 Vols. - Catalysts, Reactions, and Applications

Structured in three parts this manual recollects efficient organocatalytic transformations around clear principles that meet actual standard in asymmetric synthesis. Chapters were written by acknowledged leaders of the organocatalysis field, and are presented in a concise way. Volume 1: Privileged Catalysts gives insight to readers to the continuously increasing variety of catalysts, and the relatively complex interactions that make organocatalytic reactions selective. An appendix recollects catalyst structures with the adequate cross-references. Volume 2: Activations covers the fundamental activation types (non-covalent and covalent activations) and helps understanding the importance of physical parameters, and in particular, the role of water, that influences reactivity and selectivity. Volume 3: Reactions and Applications highlights transformations by reaction types. The final part of this volume is dedicated to application in multistep synthesis and industrial applications.Considering the ever increasing interest in the organocatalysis field, the book aims addressing to a large audience: to academic, and, industrial researchers, students and teachers who are interested in synthetic organic chemistry at advanced level. This book provides non-specialists with an introduction to the topic as well as serving as a valuable source for newcomers and researchers searching for an up-to-date and comprehensive overview of this promising area of synthetic organic chemistry.

List of contents

VOLUME ONE - Privileged CatalystsPART I: AMINO ACID-DERIVED CATALYSTSProline-Related Secondary Amine Catalysts and ApplicationsTMS-Prolinol Catalyst in OrganocatalysisNon-Proline Amino Acid CatalystsChiral Imidazolidinone (MacMillan's Catalyst)Oligopeptides as Modular Organocatalytic ScaffoldsPART II: NON-AMINO ACID-DERIVED CATALYSTSCinchonas and CupreidinesChiral C2 CatalystsPlanar Chiral CatalystsDynamic Approaches towards Catalyst DiscoveryVOLUME TWO - ActivationsPART I: ASYMMETRIC CATALYSIS WITH NON-COVALENT INTERACTIONSBronsted AcidsBronsted Acids: Chiral Phosphoric Acid Catalysts in Asymmetric SynthesisBronsted Acids: Chiral (Thio)urea DerivativesBronsted BasesChiral Onium Salts (Phase-Transfer Reactions)Lewis BasesLewis AcidsPART II: ASYMMETRIC CATALYSIS WITH COVALENT INTERACTIONSRationalizing Reactivity and Selectivity in Aminocatalytic ReactionsCarbene CatalystsOxides and EpoxidesYlidesPART III: TUNING CATALYST ACTIVITY AND SELECTIVITY BY THE REACTION MEDIUM AND CONDITIONS"Non-Classical" Activation of Organocatalytic Reactions (Pressure, Microwave Irradiation)Ionic Liquid OrganocatalystsPolymer and Mesoporous Material Supported OrganocatalystsWater in Organocatalytic ReactionsVOLUME THREE - Reactions and ApplicationsPART I: ALPHA-ALKYLATION AND HETEROATOM FUNCTIONALIZATIONSN2-Type Alpha-Alkylation and Allylation ReactionsAlpha-Alkylation by SN1-Type ReactionsAlpha-Heteroatom Functionalization of Carbonyl CompoundsPART II: NUCLEOPHILE ADDITION TO C=X BONDSAldol and Mannich-Type ReactionsAdditions of Nitroalkyls and Sulfones to C=XHydrocyanation and Strecker ReactionsThe Morita-Baylis-Hillman (MBH) and Hetero-MBH ReactionsReduction of C=O and C=NPART III: NUCLEOPHILE ADDITION TO C=C BONDSAddition to Alpha, Beta-Unsaturated Aldehydes and KetonesAddition to Nitroolefins and Vinyl SulfonesOrganocatalyzed Asymmetric Arylation and Heteroarylation ReactionsPART IV: RING-FORMING REACTIONSIntramolecular ReactionsFormation of 3-, 4- and 5-Membered Cycles by Intermolecular ReactionsDiels-Alder and Hetero-Diels-Alder ReactionsPART V: INCREASING COMPLEXITYOrganocatalytic Radical and Electron Transfer ReactionsOrganocatalytic Sigmatropic ReactionsRegio- and Position Selective Reactions and DesymmetrizationsThree or More Components Reactions (Single Catalyst Systems)Multi-Catalyst SystemsOrganocatalysis in Total Synthesis

About the author

Peter I. Dalko studied chemistry at the Budapest Technical University (Hungary) and graduated from Paris XI University (France) under the supervision of the late Stephan D. Géro. After undertaking postdoctoral researches with the late Sir Derek H. Barton at TAMU (USA) and Yoshito Kishi at Harvard University he is now a Research Director at the French Scientific Research Council (CNRS) at the Medical Faculty of the Sorbonne Paris Cité (France). His research is focused on total synthesis of structurally complex natural products, development of organocatalytic reactions for synthesis and developing microand nanoscale technologies for biomedical researches.

Summary

Structured in three parts this manual recollects efficient organocatalytic transformations around clear principles that meet actual standard in asymmetric synthesis. Chapters were written by acknowledged leaders of the organocatalysis field, and are presented in a concise way. Volume 1: Privileged Catalysts gives insight to readers to the continuously increasing variety of catalysts, and the relatively complex interactions that make organocatalytic reactions selective. An appendix recollects catalyst structures with the adequate cross-references. Volume 2: Activations covers the fundamental activation types (non-covalent and covalent activations) and helps understanding the importance of physical parameters, and in particular, the role of water, that influences reactivity and selectivity. Volume 3: Reactions and Applications highlights transformations by reaction types. The final part of this volume is dedicated to application in multistep synthesis and industrial applications.

Considering the ever increasing interest in the organocatalysis field, the book aims addressing to a large audience: to academic, and, industrial researchers, students and teachers who are interested in synthetic organic chemistry at advanced level. This book provides non-specialists with an introduction to the topic as well as serving as a valuable source for newcomers and researchers searching for an up-to-date and comprehensive overview of this promising area of synthetic organic chemistry.

Product details

• Authors: Peter I. Dalko
• Assisted by: Peter I. Dalko (Editor), Pete I Dalko (Editor), Peter I Dalko (Editor)
• Publisher: Wiley-VCH
• Languages: English, German
• Product format: Mixed media product
• Released: 26.10.2013
• EAN: 9783527332366
• ISBN: 978-3-527-33236-6
• No. of pages: 1160
• Dimensions: 179 mm x 241 mm x 95 mm
• Weight: 3896 g
• Illustrations: 1400 SW-Abb., 20 Farbabb., 60 Tabellen
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Chemie, Katalyse, chemistry, Catalysis, Organische Synthese, Methods - Synthesis & Techniques, Organische Chemie / Methoden, Synthesen, Verfahren, Sustainable Chemistry & Green Chemistry, Nachhaltige u. Grüne Chemie