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Gramicidin ist ein aus 15 Resten bestehendes antibiotisches Polypeptid, das Leitungskanäle in Lipid-Doppelschichten bildet. Neuerdings sind hochauflösende Strukturdaten des Moleküls verfügbar, so daß man den Transport eines Ions durch solche Kanäle auf molekularer Ebene erklären kann. Die wichtigsten Aspekte dieses interdisziplinären Forschungsgebietes faßt dieses Buch zusammen - kristallographische, spektroskopische und elektrophysikalische Untersuchungen werden ebenso diskutiert wie die Ergebnisse von Berechnungen. (07/99)
List of contents
From the contents:
Introduction: Gramicidin, a Model Ion Channel (B. Wallace).
Correlations of Structure, Dynamics and Function in the Gramicidin Channel by Solid-State NMR Spectroscopy (T. Cross, et al.).
X-ray Crystallographic Structures of Gramicidin and Their Relation to the Streptomyces lividans Potassium Channel Structure (B. Wallace).
Design and Characterization of Gramicidin Channels with Side Chain or Backbone Mutations (R. Koeppe, et al.).
Engineering Charge Selectivity in Alamethicin Channels (G. Woolley, et al.).
Lorentzian Noise in Single Gramicidin A Channel Formamidinium Currents (T. Fairbanks, et al.).
Can We Use Rate Constants and State Models to Describe Ion Transport Through Gramicidin Channels? (S. Hladky).
The Binding Site of Sodium in the Gramicidin A Channel (B. Roux & T. Woolf).
The Mechanism of Channel Formation by Alamethicin as Viewed by Molecular Dynamics Simulations (M. Sansom, et al.).
Ionic Interactions in Multiply Occupied Channels (V. Dorman, et al.) .
Peptide Influences on Lipids (J. Killian, et al.).
Peptide - Lipid Interactions and Mechanisms of Antimicrobial Peptides (H. Huang).
Folding Patterns of Membrane Proteins: Diversity and the Limitations of Their Prediction (J. Rosenbusch).
Molecular Basis of the Charge Selectivity of Nicotinic Acetylcholine Receptor and Related Ligand-Gated Ion Channels (P.-J. Corringer, et al.).
The Gramicidin-Based Biosensor: A Functioning Nano-Machine (B. Cornell, et al.).
Final General Discussion: Protons.
Summary: What We Have Learned About Gramicidin and Other Ion Channels.
Indexes.
