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This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes - achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic - (1) illustrating the general principles outlined above through a series of different stem cell examples - embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.
List of contents
The stem cell state.- Induction of pluripotency.- Germline stem cells and their regulation in the nematode Caenorhabditis elegans.- Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progeny.- Stem cells in the Drosophila digestive system.- Mechanisms of Asymmetric Progenitor Divisions in the Drosophila Central Nervous System.- Transcriptional / Translational Regulation of Mammalian Spermatogenic Stem Cells.- Transcriptional Regulation and Specification of Neural Stem Cells.- Transcriptional Control of Epidermal Stem Cells.- Regulation of intestinal stem cells by Wnt and Notch signalling.- Transcriptional regulation of haematopoietic stem cells.- Regulation of mesenchymal stem cell differentiation.- Molecular families implicated in stem cell regulation.- The Musashi family of RNA binding proteins: Master regulators of multiple stem cell populations.- JAK-STAT signalling in stem cells.- Myc in Stem Cell Behaviour: insights from Drosophila.- The Role of Nuclear Receptors in Embryonic Stem Cells.- Epigenetic regulation of stem cells.- Regulation of stem cell populations by microRNAs.- Myb and the Regulation of stem cells in the Intestine and Brain: A Tale of Two Niches.
Summary
This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.
