Diversity-Oriented Synthesis - Basics Applications in Organic Synthesis, Drug Discovery, Chemical

Informationen zum Autor ANDREA TRABOCCHI, PhD, is Assistant Professor of Organic Chemistry at the University of Florence. Dr. Trabocchi leads research in diversity-oriented synthesis, peptidomimetic chem-istry, chemical genetics, and conformational analysis. Klappentext Discover an enhanced synthetic approach to developing and screening chemical compound librariesDiversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology.Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book:* Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles* Expands on the concept of diversity-oriented synthesis by describing chemical libraries* Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays* Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical researchThis book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications.Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications. Zusammenfassung This book reviews diversity-oriented synthesis (DOS), a leading and dynamic area in organic chemistry and drug discovery. It first covers key chemical methods for the generation of small molecules according to DOS principles as well as important classes of molecules generated through DOS approaches. Inhaltsverzeichnis CONTRIBUTORS xv FOREWORD xix PREFACE xxi ABBREVIATIONS xxv 1 The Basics of Diversity-Oriented Synthesis 1 Kieron M. G. O'Connell, Warren R. J. D. Galloway, and David R. Spring 1.1 Introduction, 1 1.2 What Is Diversity-Oriented Synthesis?, 1 1.3 Small Molecules and Biology, 2 1.4 Comparing DOS, TOS, and Combinatorial Chemistry: Focused Library Synthesis, 4 1.5 Molecular Diversity, 5 1.6 Molecular Diversity and Chemical Space, 8 1.7 Synthetic Strategies for Creating Molecular Diversity, 8 1.8 Reagent-Based Approaches to Diversity Generation, 11 1.9 Substrate-Based Approach to Skeletal Diversity Generation, 19 1.10 Other Build/Couple/Pair Examples, 19 1.11 Concluding Remarks, 24 PART I CHEMICAL METHODOLOGY IN DIVERSITY-ORIENTED SYNTHESIS 2 Strategic Applications of Multicomponent Reactions in Diversity-Oriented Synthesis 29 John M. Knapp, Mark J. Kurth, Jared T. Shaw, and Ashkaan Younai 2.1 Introduction, 29 2.2 MCR Products for HTS, 31 2.3 MCRs as Starting Points for DOS, 39 <...

Product details

• Authors: Trabocchi, A Trabocchi, Andrea Trabocchi
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 23.08.2013
• EAN: 9781118145654
• ISBN: 978-1-118-14565-4
• No. of pages: 664
• Subject: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry