Role of Capsaicin in Oxidative Stress and Cancer

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

List of contents

Preface.- Role of capsaicin in cancer prevention.- Role of death receptors belonging to the TNF family in capsaicin-induced apoptosis of tumor cells.- Role of capsaicin in prostate cancer.- Capsaicin and the urinary bladder.- Inhibition of pancreatitis and carcinogenesis by capsaicin.- Cytochrome P450-dependent modification of capsaicinoids: pharmacological inactivation and bioactivation mechanisms.- The cancer suppressing and promoting actions of capsaicin.- Oxidative stress by capsaicin in cancer.

Summary

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Product details

• Assisted by: Sanja K Srivastava (Editor), Sanjay K Srivastava (Editor), Sanjay K. Srivastava (Editor)
• Publisher: Springer Netherlands
• Languages: English
• Product format: Hardback
• Released: 31.05.2013
• EAN: 9789400763166
• ISBN: 978-94-0-076316-6
• No. of pages: 178
• Dimensions: 161 mm x 243 mm x 19 mm
• Weight: 462 g
• Illustrations: IX, 178 p.
• Series: Diet and Cancer; Diet and Cancer
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; B, Medicine, Science, Humanities and Social Sciences, multidisciplinary, Humanities and Social Sciences, Pharmacology, Interdisciplinary studies, Cancer Research, Medical Genetics, Cellular biology (cytology), Biomedical Research, Cell Biology, Genetics (non-medical), Pharmacology/Toxicology, Gene Expression, Apoptosis, Cancer;Capsaicin;Oxidative stress;Prevention;Therapy