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Informationen zum Autor RAMON RIOS TORRES, PhD, is Reader in Organic Chemistry at the University of Southampton. With more than ninety peer-reviewed articles and several book chapters to his credit, Dr. Rios Torres devotes his research to the development of new asymmetric methods based on organocatalysis and organometallic chemistry as well as the application of these methods in total synthesis. Dr. Rios Torres is also the editor of The Pauson-Khand Reaction: Scope, Variations and Applications (Wiley). Klappentext Sets forth an important group of environmentally friendly organic reactionsWith contributions from leading international experts in organic synthesis, this book presents all the most important methodologies for stereoselective organocatalysis, fully examining both the activation mode as well as the type of bond formed. Clear explanations guide researchers through all the most important methods used to form key chemical bonds, including carbon-carbon (C-C), carbon-nitrogen (C-N), and carbon-halogen (C-X) bonds. Moreover, readers will discover how the use of non-metallic catalysts facilitates a broad range of important reactions that are environmentally friendly and fully meet the standards of green chemistry.Stereoselective Organocatalysis begins with an historical overview and a review of activation modes in asymmetric organocatalysis. The next group of chapters is organized by bond type, making it easy to find bonds according to their applications. The first of these chapters takes a detailed look at the many routes to C-C bond formation. Next, the book covers:* Organocatalytic C-N bond formation* C-O bond formation* C-X bond formation* C-S, C-Se, and C-B bond formation* Enantioselective organocatalytic reductions* Cascade reactions forming both C-C bonds and C-heteroatom bondsThe final chapter is devoted to the use of organocatalysis for the synthesis of natural products. All the chapters in the book are extensively referenced, serving as a gateway to the growing body of original research reports and reviews in the field.Based on the most recent findings and practices in organic synthesis, Stereoselective Organocatalysis equips synthetic chemists with a group of organocatalytic reactions that will help them design green reactions and overcome many challenges in organic synthesis. Zusammenfassung This book covers the most important methodologies reported for stereoselective organocatalysis, based not only on the activation mode but also the type of bond formed. Inhaltsverzeichnis PREFACE vii CONTRIBUTORS ix 1. INTRODUCTION: A HISTORICAL POINT OF VIEW 1 Ramon Rios and Xavier Companyó 2. ACTIVATION MODES IN ASYMMETRIC ORGANOCATALYSIS 11 Albert Moyano 3. C-C BOND FORMATION BY ALDOL REACTION 81 Dorota Gryko and Dominika Walaszek 4. EXAMPLES OF METAL-FREE DIRECT CATALYTIC ASYMMETRIC MANNICH-TYPE REACTIONS USING AMINOCATALYSIS 129 Armando Córdova 5. C-C BOND FORMATION BY MICHAEL REACTION 147 Yong Zhang and Wei Wang 6. C-C BOND FORMATION BY DIELS-ALDER AND OTHER PERICYCLIC REACTIONS 205 Johan Franzén 7. N-HETEROCYCLIC CARBENE-CATALYZED C-C BOND FORMATION 231 Xiang-Yu Chen and Song Ye 8. a-ALKYLATION OF CARBONYL COMPOUNDS 267 Marek Remeš and Jan Veselý 9. OTHER REACTIONS FOR C-C BOND FORMATION 313 Yi-Xia Jia and Tiexin Zhang 10. CASCADE REACTIONS FORMING C-C BONDS 351 Ramon Rios, Jorge Esteban, and Xavier Companyó 11. ORGANOCATALYTIC C-N BOND FORMATION 381 Aitor Landa, Rosa López, Antonia Mielgo, Mikel Oiarbide, and Claudio Palomo 12. C-O BOND FORMATION 433 José Alemán and Mariola Tortosa 13. CARBON-HALOGEN BOND FORMATION 46...
