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Experts investigate the biochemical and biomedical aspects of cholesterol, addressing its metabolism in normal and disease states. They discuss a broad range of topics, including key steps in the cholesterol biosynthetic pathway, and the role of cholesterol in cancer, atherosclerosis, and diseases of the nervous system. The book's comprehensive coverage also includes the pathological consequences and potential therapies for various disease states, and the development of new anti-atherogenic drugs.
List of contents
1 Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway.- 2 Coordinate Regulation of Cholesterol 7?-Hydroxylase and HMG-CoA Reductase in the Liver.- 3 Polyprenyl Diphosphate Synthases.- 4 Antifungal Sterol Biosynthesis Inhibitors.- 5 The Smith-Lemli-Opitz Syndrome: A Potentially Fatal Birth Defect Caused by a Block in the Last Enzymatic Step in Cholesterol Biosynthesis.- 6 Has Nature Designed the Cholesterol Side Chain for Optimal Interaction with Phospholipids?.- 7 Cholesterol and Myelin.- 8 Regulation of Mitochondrial Cholesterol Metabolism.- 9 Lipoproteins and Cellular Cholesterol Homeostasis.- 10 Cholesterol-Sphingomyelin Interactions in Cells-Effects on Lipid Metabolism.- 11 Mechanisms and (Patho)Physiological Significance of Biliary Cholesterol Secretion.- 12 Cholesterol Deposition in Atherosclerotic Lesions.- 13 Cholesterol Metabolism and Tumor Cell Proliferation.- 14 Biological Implications of the Niemann-Pick C Mutation.- 15 Sitosterolemia.- 16 Cholesterol Cytochemistry in Cell Biology and Disease.- 17 Approaches for the Design of Novel Anti-Atherogenic Compounds.
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`An excellent and up-to-date overview...A useful volume for libraries, investigators, or graduate students.'
Inform, September 1998
