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Klappentext There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. Zusammenfassung There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights principles of immune suppression that drive cancer! and it offers radically new ideas about how therapy can be improved by attacking these principles. Inhaltsverzeichnis Part I: Principles of Cancer Immunobiology IntroductionCancer Immunoediting: From Immune Surveillance to Immune EscapeImmunosurveillance: Innate and Adaptive Anti-Tumor ImmunityCytokine Regulation of Immune Tolerance to TumorsImmunological Sculpting: Natural Killer Cell Receptors and LigandsImmune Escape: Immunosuppressive Networks Part II: Cancer Therapeutics Cytotoxic Chemotherapy in Clinical Treatment of CancerTargeted Therapeutics in Cancer TreatmentConcepts in Pharmacology and ToxicologyCancer Immunotherapy: Challenges and OpportunitiesCancer Vaccines Part III: Targets and Tactics to Improve Cancer Immunotherapy By Defeating Immune Suppression Immunotherapy and Cancer Therapeutics: Why Partner?Immune Stimulatory Features of Classical ChemotherapyDendritic Cells and Co-Inhibitory MoleculesRegulatory T Cells in Tumor Immunity: Role of Toll-like Receptors Tumor-associated Macrophages in Cancer Growth and ProgressionTumor-associated Myeloid-derived Suppressor CellsProgrammed Death Ligand-1 and Galectin-1: Pieces in the Puzzle of Tumor Immune EscapeIDO in Immune Escape: Regulation and Therapeutic InhibitionArginase, Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in Immune ModulationSummary: Future Questions...
