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The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blokcade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study.
List of contents
Preface.- Chapter 1 Overview of signal transduction in tumor metastasis.- Chapter 2 Multiple signal pathway triggering initiation of tumor metastasis.- Chapter 3 Insights into the dynamics of focal adhesion protein trafficking in invasive cancer cells and clinical implications.- Chapter 4 Grb2 and other adaptor proteins in tumor metastasis.- Chapter 5 ERK1/2 MAP Kinase Signaling in Tumor Invasion and Metastasis.- Chapter 6 MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASES AND METASTASIS.- Chapter 7 The signaling mechanism of ROS in tumor progression.- Chapter 8 Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species.- Chapter 9 Notch signaling and cancer metastasis.- Chapter 10 New concepts on the critical functions of cancer- and metastasis-initiating cells in treatment resistance and disease relapse: Molecular mechanisms, signaling transduction elements and novel targeting therapies.- Chapter 11 Involvement of lipid rafts in Growth factor receptors-mediated signaling for cancer metastasis.- Chapter 12 Signal Transduction Pathways involved in Metastatic Liver Cancer.- Chapter 13 Cadherins and signaling in ovarian cancer progression.- Chapter 14 PTP4A3, a signal molecule deregulated in Uveal melanoma metastasis.
Summary
This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.
