Fr. 165.00

Reverse Genetics of Rna Viruses - Applications and Perspectives

English · Hardback

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Informationen zum Autor Dr Anne Bridgen , previously of The University of Ulster is a molecular virologist with extensive research and teaching experience. She was the first scientist to recover infectious virus particles from DNA clones of a segmented RNA virus. Dr Bridgen knows the field and its main players well and has both the knowledge and experience to bring individual expert contributions together around the common theme of reverse genetics. She is currently providing consultancy for a BBSRC grant based at IAH Pirbright. Klappentext Reverse genetics, the manipulation of the DNA of RNA viruses to create a modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells over the past fourteen years. Since most severe viral human and animal pathogens are RNA viruses, including those responsible for polio, hepatitis and influenza, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases.Written by a team of international experts in the field, this book provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. From influenza A virus vaccines, to fluorescent measles virus and quasispecies, this guide explores the progress researchers have made in our current understanding of viral disease and considers where possible applications may lead in the future. Zusammenfassung Reverse genetics, the manipulation of the DNA of RNA viruses to create a modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells over the past fourteen years. Since most severe viral human and animal pathogens are RNA viruses, including those responsible for polio, hepatitis and influenza, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases.Written by a team of international experts in the field, this book provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. From influenza A virus vaccines, to fluorescent measles virus and quasispecies, this guide explores the progress researchers have made in our current understanding of viral disease and considers where possible applications may lead in the future. Inhaltsverzeichnis List of contributors xiAcknowledgements xiii1 Introduction 1Anne Bridgen1.1 Background 11.2 Reverse genetics for different classes of genome 21.3 Methodology 51.4 Difficulties in establishing a reverse genetics system 111.5 Recent developments 131.6 Are there any boundaries for conducting reverse genetics? 13References 15Part I Positive sense RNA viruses 252 Coronavirus reverse genetics 27Maria Armesto, Kirsten Bentley, Erica Bickerton, Sarah Keep and Paul Britton2.1 The Coronavirinae 272.2 Infectious bronchitis 282.3 Coronavirus genome organisation 292.4 The coronavirus replication cycle 302.5 Development of reverse genetics system for coronaviruses including IBV 332.6 Reverse genetics system for IBV 372.7 Reverse genetics systems for the modification of coronavirus genomes 402.8 Using coronavirus reverse genetics systems for gene delivery 49Acknowledgements 51References 513 Reverse genetic tools to study hepatitis C virus 64Alexander Ploss3.1 Introduction: hepatitis C 643.2 Hepatitis C virus 653.3 Construction of infectious clones for hepatitis C virus 683.4 Study of HCV RNA replication in cell culture systems 683.5 Use of HCV...

Product details

Authors a Bridgen, Anne Bridgen, BRIDGEN ANNE
Publisher Wiley, John and Sons Ltd
 
Languages English
Product format Hardback
Released 02.11.2012
 
EAN 9780470979655
ISBN 978-0-470-97965-5
No. of pages 408
Subjects Natural sciences, medicine, IT, technology > Biology > General, dictionaries

Virologie, Life Sciences, Biowissenschaften, Virology, Klinische Mikrobiologie, Clinical Microbiology, Ribonukleinsäure

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