Transporters in Drug Discovery and Development - Detailed Concepts and Best Practice

Informationen zum Autor Yurong Lai is a senior principal scientist at a US-based pharmaceutical company. He received his M.D. from Fujian Medical University in China and a Ph.D. (Toxicology) from Sapporo Medical University in Japan. From 1998 to 2001, he was a research fellow of Japanese Society for Promotion (JSPS) in Department of Physiopathology, Graduate School of Medicine of Hokkaido University, followed by a position as Research Associate in Department of Pharmaceutics, University of Washington Zusammenfassung Written by a leading researcher in the field, Transporters in drug discovery and development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development.

List of contents

Membrane transporters and the diseases corresponding to functional defects; P-glycoprotein (P-gp/MDR1)/ABCB1; Multidrug resistance- associated protein 2 (MRP2/ABCC2); Breast cancer resistance protein (BCRP)/ABCG2; The bile salt export pump (BSEP/ABCB11); Organic anion- transporting polypeptides (OATPs/SLCOs); Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs); Drug transporters in drug discovery and development; Transporter study methodologies.

Product details

• Authors: Yurong Lai, Yurong (A Major Us Pharmaceutical Company Lai, Lai Yurong, Lai Yurong
• Publisher: ELSEVIER SCIENCE BV
• Languages: English
• Product format: Hardback
• Released: 31.10.2013
• EAN: 9781907568213
• ISBN: 978-1-907568-21-3
• No. of pages: 780
• Series: Woodhead Publishing Series in; Woodhead Publishing Series in Biomedicine
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; Social sciences, law, business > Business > Individual industrial sectors, branches; SCIENCE / Life Sciences / Biochemistry, MEDICAL / Pharmacology, SCIENCE / Life Sciences / Molecular Biology, biochemistry, molecular biology, Pharmacology, Pharmaceutical technology, Pharmaceutical chemistry and technology, TECHNOLOGY & ENGINEERING / Pharmaceutical