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Informationen zum Autor TOSHIHISA ISHIKAWA, PhD, is Senior Scientist at RIKEN Yokohama Institute and Professor of Biochemistry, Molecular Biology, and Pharmacogenomics at Yokohama City University's Graduate School of Medicine. Previously, Dr. Ishikawa was the Director of the Department of Research Technology Development at Pfizer, Japan. A recipient of the Achievement Award from the International Life Sciences Institute (ILSI), Dr. Ishikawa is also the cofounder of the International Transporter Consortium (ITC). RICHARD B. KIM, MD, FRCPC, is Professor and Chair of the Division of Clinical Pharmacology and Associate Chair for Research in the Department of Medicine at the University of Western Ontario. He is a Fellow of the American Association of Pharmaceutical Scientists and an elected member of the American Society for Clinical Investigation. JÖRG KÖNIG , PhD, is Professor and Head of the Molecular Biology Laboratories in the Department of Clinical Pharmacology at the Friedrich-Alexander Universität Erlangen-Nürnberg. Klappentext Sets the foundation for safer, more effective drug therapiesWith this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics.Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including:* Individual drug transporters and transporter families and their clinical significance* Principles of altered drug transport in drug-drug interactions, pharmacotherapy, and personalized medicine* Emerging new technologies for rapid detection of genetic polymorphisms* Clinical aspects of genetic polymorphisms in major drug transporter genes* Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicinePharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers. Zusammenfassung Highlighting the internationally hot topic of pharmacogenomics and its influence on drug therapy, Pharmacogenomics of Human Drug Transporters reviews individual drug transporters, including specific transporter families and clinical implications. Inhaltsverzeichnis PREFACE vii CONTRIBUTORS ix CHAPTER 1 INTRODUCTION TO PHARMACOGENOMICS OF DRUG TRANSPORTERS 1 Marianne K. DeGorter and Richard B. Kim CHAPTER 2 ADME PHARMACOGENOMICS IN DRUG DEVELOPMENT 13 Liangfu Chen and Joseph W. Polli CHAPTER 3 REGULATORY PERSPECTIVE ON PHARMACOGENOMICS OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS 39 Lei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew-Mei Huang CHAPTER 4 THE PHARMACOGENOMICS OF MEMBRANE TRANSPORTERS PROJECT 73 Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini CHAPTER 5 EMERGING NEW TECHNOLOGY OF SNP TYPING 109 Toshihisa Ishikawa and Yoshihide Hayashizaki CHAPTER 6 OATP1A2, OAT1, AND OA...
