Devalued and Distrusted - Can the Pharmaceutical Industry Restore Its Broken Image?

Informationen zum Autor JOHN L. LaMATTINA, PHD, retired as president of Pfizer's Global Research and Development in 2007, where he managed more than 13,000 scientists and support professionals in the United States, Europe, and Asia. Dr. LaMattina has received numerous honors and awards, including an Honorary Doctor of Science from the University of New Hampshire. Currently a Senior Partner with PureTech Ventures, he is the author of Drug Truths: Dispelling the Myths About Pharma R&D (Wiley). Klappentext An expert's view on solving the challenges confronting today's pharmaceutical industryAuthor John LaMattina, a thirty-year veteran of the pharmaceutical industry and former president of Pfizer's Global R&D Division, is internationally recognized as an expert on the pharmaceutical industry. His first book, Drug Truths: Dispelling the Myths About Pharma R&D, was critically acclaimed for clearing up misconceptions about the pharmaceutical industry and providing an honest account of the contributions of pharmaceutical research and development to human health and well-being.As he toured the country discussing Drug Truths, Dr. LaMattina regularly came across people who were filled with anger, accusing the pharmaceutical industry of making up diseases, hiding dangerous side effects, and more. This book was written in response to that experience, critically examining public perceptions and industry realities.Starting with "4 Secrets that Drug Companies Don't Want You to Know," Devalued and Distrusted provides a fact-based account of how the pharmaceutical industry works and the challenges it faces. It addresses such critical issues as:* Why pharmaceutical R&D productivity has declined* Where pharmaceutical companies need to invest their resources* What can be done to solve core health challenges, including cancer, diabetes, and neurodegenerative diseases* How the pharmaceutical industry can regain public trust and resuscitate its imageOur understanding of human health and disease grows daily; however, converting science into medicine is increasingly challenging. Reading Devalued and Distrusted, you'll not only gain a greater appreciation of those challenges, but also the role that the pharmaceutical industry currently plays and can play in solving those challenges.Get to know the author: Read an interview with John LaMattina or watch a video on ChemistryViews!Interview: John LaMattina: 30 Years in PharmaVideo: Can the Pharmaceutical Industry Restory its Broken Image? Zusammenfassung An expert's view on solving the challenges confronting today's pharmaceutical industry Author John LaMattina, a thirty-year veteran of the pharmaceutical industry and former president of Pfizer's Global R&D Division, is internationally recognized as an expert on the pharmaceutical industry. Inhaltsverzeichnis ACKNOWLEDGMENTS ix INTRODUCTION 1 CHAPTER 1 THE FOUR SECRETS THE DRUG COMPANIES DON'T WANT YOU TO KNOW 4 Drug Companies Underestimate Dangerous Side Effects 5 Drug Companies Control Much of the Information Your Doctor Gets 10 You're Often Prescribed Drugs That You Don't Need 14 Drugs Target the Symptoms, Not the Cause 19 Conclusion 22 References 23 CHAPTER 2 WHAT HAS HAPPENED TO R&D PRODUCTIVITY? 25 Impact of Mergers on R&D Productivity 26 Heightened FDA Requirements for NDAs 34 Higher Hurdles Set by Payers 41 Conclusion 46 References 48 CHAPTER 3 KEY THERAPEUTIC AREAS FOR IMPROVING HEALTH 49 Cancer 51 Diseases of the Brain 54 Cardiovascular Disease (CVD) 60 Diabetes 63 Bacterial Infections 65 Conclusion 68 References 69 CHAPTER 4 IMPROVING R&D OUTPUT 71 The Views of Others 72 Pharma's Blockbuster Mentality Needs to Change 72 Can "Predictive Innovation" Lead to Greater Success Rates? 76 ...

List of contents

ACKNOWLEDGMENTS ix
 
INTRODUCTION 1
 
CHAPTER 1 THE FOUR SECRETS THE DRUG COMPANIES DON'T WANT YOU TO KNOW 4
 
Drug Companies Underestimate Dangerous Side Effects 5
 
Drug Companies Control Much of the Information Your Doctor Gets 10
 
You're Often Prescribed Drugs That You Don't Need 14
 
Drugs Target the Symptoms, Not the Cause 19
 
Conclusion 22
 
References 23
 
CHAPTER 2 WHAT HAS HAPPENED TO R&D PRODUCTIVITY? 25
 
Impact of Mergers on R&D Productivity 26
 
Heightened FDA Requirements for NDAs 34
 
Higher Hurdles Set by Payers 41
 
Conclusion 46
 
References 48
 
CHAPTER 3 KEY THERAPEUTIC AREAS FOR IMPROVING HEALTH 49
 
Cancer 51
 
Diseases of the Brain 54
 
Cardiovascular Disease (CVD) 60
 
Diabetes 63
 
Bacterial Infections 65
 
Conclusion 68
 
References 69
 
CHAPTER 4 IMPROVING R&D OUTPUT 71
 
The Views of Others 72
 
Pharma's Blockbuster Mentality Needs to Change 72
 
Can "Predictive Innovation" Lead to Greater Success Rates? 76
 
Would Royalties Make Scientists More Productive? 78
 
Will Drug Repositioning Help Fill the R&D Pipeline? 80
 
Consultants Don't Always Have the Facts 82
 
Personal Views 84
 
Discovery Must Focus on Productivity 85
 
Does Size Help or Hinder R&D Productivity? 87
 
To Outsource or Not to Outsource? That's the Pharma R&D Question 89
 
Big Pharma Early Research Collaborations 92
 
Conclusion 93
 
References 95
 
CHAPTER 5 RESTORING PHARMA'S IMAGE 96
 
Illegal Detailing of Drugs 97
 
Pharmaceutical Companies Should Drop TV Ads 98
 
The Need for Greater Transparency 100
 
How Committed Is Big Pharma to Rare Diseases? 102
 
Pharmaceutical Companies and Philanthropy 104
 
Pharma Needs to Have Its Scientists Tell Their Stories 105
 
Conclusion 106
 
References 107
 
CHAPTER 6 FINAL THOUGHTS 109
 
References 114
 
INDEX 115

Report

"Oz should invite LaMattina back on his show. Since LaMattina treats all concerns respectfully, Oz needn't worry about feeling devalued or distrusted." (Barron's, 5 May 2014)
 
"This is an honest book by an insider who believes in the basic good that the industry does." (The Quarterly Review of Biology, 1 September 2013)
 
"Summing Up: Recommended. General audiences." (Choice, 1 September 2013)
 
"For those more loosely associated or aspiring to work with in it, I particularly recommend this book as a balanced and informative read on the pressures the industry faces. It should also provide the basis for more reasoned argument and forewarn anyone else potentially ambushed by a TV show." (ChemMedChem, 19 July 2013)
 
"That said, the suggestions made by LaMattina for improvements in productivity and transparency are timely, and the book makes interesting if unexciting reading." (Chemistry & Industry, 1 June 2013)
 
"John LaMattina (ex-head of Pfizer's global R&D) has a new book out about the industry, called Devalued and Distrusted. He tells Pharmalot that he got the idea to write a sequel to his earlier book, Drug Truths, when he appeared on the "Dr. Oz" show." (In The Pipeline, 1 December 2012)

Product details

• Authors: Jl Lamattina, John L Lamattina, John L. Lamattina, LaMattina John L.
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Paperback / Softback
• Released: 19.02.2013
• EAN: 9781118487471
• ISBN: 978-1-118-48747-1
• No. of pages: 136
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; Non-fiction book > Nature, technology > Natural science; Social sciences, law, business > Business > Individual industrial sectors, branches; Chemie, Medizin, pharmazeutische industrie, chemistry, Pharmacology & Pharmaceutical Medicine, Pharmakologie u. Pharmazeutische Medizin, Wirkstoffforschung u. -entwicklung, Drug Discovery & Development, Medical Science, Biochemie u. Chemische Biologie, Biochemistry (Chemical Biology)