Perinatal Stem Cells

Informationen zum Autor Kyle J. Cetrulo is the founder and CEO of Auxocell Laboraties, Inc, as well as the founder and Director of the Perinatal Stem Cell Society.?Co-editor of the first edition of Perinatal Stem Cells, Dr. Cetrulo is an active member of the stem cell research community, serving as Director of the International Cord Blood Society since 1998. Curtis Cetrulo Jr., M.D. is Assistant Professor of Surgery at Harvard Medical School, Boston. A co-editor of the first edition of Perinatal Stem Cells, he is also Director of the Reconstructive Transplantation Service in the Divisions of Transplant Surgery and Plastic and Reconstructive Surgery at Massachusetts General Hospital, and a senior investigator for the Composite Tissue Allograft Laboratory at Massachusetts General. Klappentext Perinatal Stem Cells, 2nd Edition builds on the first edition to provide an updated tutorial on perinatal stem cells, including stem cells harvested from the amniotic fluid, placenta, maternal blood supply, umbilical cord and Wharton's Jelly. As in the first edition, coverage includes the underlying biology of each of the sources of pregnancy related stem cells, cell culture, and potential therapeutic uses, as well as insights on the impact of these stem cells from obstetricians and gynecologists, cardiologists, hematologists, tissue engineers, and cord blood bankers.Normally discarded as medical waste, perinatal stem cells offer a powerful therapeutic tool box alternative to the controversial embryonic stem cells. Since publication of the first edition, a burgeoning commerical industry has developed around various sources of perinatal cells, and the second edition now includes an overview of this growing industry.With contributions from some of the top academic stem cell laboratories in the United States as well as new chapters from international stem cell scientists, Perinatal Stem Cells presents an update on the cutting-edge research in the field while maintaining its signature clinical focus. Zusammenfassung * Thorough update of the field-defining text * Now includes contributions from international authors * Written by a diverse group of researchers representing OB/GYNs, hematologists, blood bank scientists and tissue engineers * Includes new chapters on the growing perinatal stem cell industry . Inhaltsverzeichnis Contributors xi Introduction xv 1 AMNIOTIC FLUID STEM CELLS 1 Sean Vincent Murphy and Anthony Atala Introduction 1 Development of Gestational Stem Cells 2 Isolation and Characterization of Amniotic Fluid Stem Cells 2 Multipotency of Amniotic Fluid Stem Cells 3 Clinical Application of Amniotic Fluid Stem Cells 8 Conclusion 13 References 13 2 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE 17 Richard L. Haspel and Karen K. Ballen Introduction 17 Hematopoietic Stem Cell Transplants: Adult Donor Collection 17 Hematopoietic Stem Cell Transplants: HLA Matching 18 Collection and Processing of Cord Blood Units 19 Hematopoietic Stem Cell Transplants: Recipient Issues 20 Bone Marrow versus Single Cord Blood: Pediatric 21 Bone Marrow versus Cord Blood: Adults 23 Cord Blood Transplant: Advantages and Disadvantages 23 Double Cord Blood Transplants: Ablative Regimens 24 Double Cord Blood Transplant: Non-Myeloablative Regimens 26 Are Two Cords Better Than One? 27 Chimerism 28 Predicting the Winner 28 Other Experimental Strategies 30 Summary 31 References 31 3 HEMATOPOIETIC STEM CELL DEVELOPMENT IN THE PLACENTA 37 Katrin E.R. Ericson, Akanksha Chhabra, and Hanna K.A. Mikkola Introduction 37 The Hematopoietic System 37 Historical Perspective on Placental Hematopoiesis 38 The Development and S...

List of contents

Contributors xi
 
Introduction xv
 
1 AMNIOTIC FLUID STEM CELLS 1
Sean Vincent Murphy and Anthony Atala
 
Introduction 1
 
Development of Gestational Stem Cells 2
 
Isolation and Characterization of Amniotic Fluid Stem Cells 2
 
Multipotency of Amniotic Fluid Stem Cells 3
 
Clinical Application of Amniotic Fluid Stem Cells 8
 
Conclusion 13
 
References 13
 
2 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE 17
Richard L. Haspel and Karen K. Ballen
 
Introduction 17
 
Hematopoietic Stem Cell Transplants: Adult Donor Collection 17
 
Hematopoietic Stem Cell Transplants: HLA Matching 18
 
Collection and Processing of Cord Blood Units 19
 
Hematopoietic Stem Cell Transplants: Recipient Issues 20
 
Bone Marrow versus Single Cord Blood: Pediatric 21
 
Bone Marrow versus Cord Blood: Adults 23
 
Cord Blood Transplant: Advantages and Disadvantages 23
 
Double Cord Blood Transplants: Ablative Regimens 24
 
Double Cord Blood Transplant: Non-Myeloablative Regimens 26
 
Are Two Cords Better Than One? 27
 
Chimerism 28
 
Predicting the Winner 28
 
Other Experimental Strategies 30
 
Summary 31
 
References 31
 
3 HEMATOPOIETIC STEM CELL DEVELOPMENT IN THE PLACENTA 37
Katrin E.R. Ericson, Akanksha Chhabra, and Hanna K.A. Mikkola
 
Introduction 37
 
The Hematopoietic System 37
 
Historical Perspective on Placental Hematopoiesis 38
 
The Development and Structure of the Mouse Placenta 39
 
Hematopoietic Activity in the Mouse Placenta 40
 
Identification of Placental HSCs 42
 
The Origin and Localization of Placental HSCs 43
 
Hematopoietic Activity in the Human Placenta 45
 
Hematopoietic Microenvironment in the Placenta 46
 
Conclusions and Perspectives 47
 
References 49
 
4 PERINATAL MESENCHYMAL STEM CELL BANKING FOR UMBILICAL CORD BLOOD TRANSPLANTATION AND REGENERATIVE MEDICINE 53
Rouzbeh R. Taghizadeh
 
Introduction 53
 
Hematopoiesis 54
 
Hematopoietic Transplantations 54
 
Umbilical Cord: Source of Perinatal HSCs and MSCs 56
 
Hematopoietic Transplantations of Umbilical Cord Blood 57
 
Strategies to Overcome the Transplant-Related Limitations of Umbilical Cord Blood 58
 
Umbilical Cord Tissue MSC Banking 61
 
References 63
 
5 MAKING ORGAN AND STEM CELL TRANSPLANTATION SAFER: THE ROLE OF MESENCHYMAL STEM CELLS 71
Hans Klingemann
 
Introduction 71
 
MSC to Prevent Rejection After Solid Organ Transplantation 72
 
MSC in the Treatment of Graft-versus-Host Disease 73
 
MSC to Support Hematopoietic Recovery of Stem Cells After Stem Cell Transplantation 74
 
References 75
 
6 WHARTON'S JELLY MESENCHYMAL STEM CELLS AND IMMUNE MODULATION: REGENERATIVE MEDICINE MEETS TISSUE REPAIR 77
Rita Anzalone, Felicia Farina, Melania Lo Iacono, Simona Corrao, Tiziana Corsello, Giovanni Zummo, and Giampiero La Rocca
 
Introduction 77
 
Expression of Relevant Immunomodulatory Molecules in Vitro by MSCs 79
 
Tolerance Induction by MSCs: Rediscovering the Embryo Immune Evasion Mechanisms 79
 
Immune Modulation in Vivo: Contrasting Data on the Immune Privilege of MSCs 80
 
WJ-MSC in in Vivo Models: Enhancing the Immunomodulatory Features of Adult MSC Populations 82
 
Conclusions and Future Perspectives 83
 
References 84
 
7 IMMUNOGENICITY VERSUS IMMUNOMODULATION OF PERINATAL STEM CELLS 89
Bram Lutton and Raimon Duran-Struuck
 
Introduction 89

Report

"A classic text, focuses on recent research and advances in the clinical use of mesenchyme stem cells from pregnancy sources." ( Pediatric Endocrinology Reviews , 1 June 2014)

Product details

• Authors: Curtis L. Cetrulo, Kj Cetrulo, Kyle Cetrulo, Kyle Cetrulo Cetrulo, Rouzbeh R. Taghizadeh
• Assisted by: Curtis L Cetrulo (Editor), Curtis L. Cetrulo (Editor), Kyle Cetrulo (Editor), Cetrulo Curtis L. (Editor), Cetrulo Kyle (Editor), Curti L Cetrulo (Editor), Curtis L Cetrulo (Editor), Rouzbeh R Taghizadeh (Editor), Rouzbeh R Taghizadeh (Editor), Rouzbeh R. Taghizadeh (Editor), Taghizadeh Rouzbeh R. (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 23.04.2013
• EAN: 9781118209448
• ISBN: 978-1-118-20944-8
• No. of pages: 320
• Subjects: Natural sciences, medicine, IT, technology > Biology > Genetics, genetic engineering; Genetik, Hämatologie, Medizin, Life Sciences, genetics, Biowissenschaften, Hematology, Stammzelle, Zell- u. Molekularbiologie, Cell & Molecular Biology, Medical Science