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Informationen zum Autor Kyle J. Cetrulo is the founder and CEO of Auxocell Laboraties, Inc, as well as the founder and Director of the Perinatal Stem Cell Society.?Co-editor of the first edition of Perinatal Stem Cells, Dr. Cetrulo is an active member of the stem cell research community, serving as Director of the International Cord Blood Society since 1998. Curtis Cetrulo Jr., M.D. is Assistant Professor of Surgery at Harvard Medical School, Boston. A co-editor of the first edition of Perinatal Stem Cells, he is also Director of the Reconstructive Transplantation Service in the Divisions of Transplant Surgery and Plastic and Reconstructive Surgery at Massachusetts General Hospital, and a senior investigator for the Composite Tissue Allograft Laboratory at Massachusetts General. Klappentext Perinatal Stem Cells, 2nd Edition builds on the first edition to provide an updated tutorial on perinatal stem cells, including stem cells harvested from the amniotic fluid, placenta, maternal blood supply, umbilical cord and Wharton's Jelly. As in the first edition, coverage includes the underlying biology of each of the sources of pregnancy related stem cells, cell culture, and potential therapeutic uses, as well as insights on the impact of these stem cells from obstetricians and gynecologists, cardiologists, hematologists, tissue engineers, and cord blood bankers.Normally discarded as medical waste, perinatal stem cells offer a powerful therapeutic tool box alternative to the controversial embryonic stem cells. Since publication of the first edition, a burgeoning commerical industry has developed around various sources of perinatal cells, and the second edition now includes an overview of this growing industry.With contributions from some of the top academic stem cell laboratories in the United States as well as new chapters from international stem cell scientists, Perinatal Stem Cells presents an update on the cutting-edge research in the field while maintaining its signature clinical focus. Zusammenfassung * Thorough update of the field-defining text * Now includes contributions from international authors * Written by a diverse group of researchers representing OB/GYNs, hematologists, blood bank scientists and tissue engineers * Includes new chapters on the growing perinatal stem cell industry . Inhaltsverzeichnis Contributors xi Introduction xv 1 AMNIOTIC FLUID STEM CELLS 1 Sean Vincent Murphy and Anthony Atala Introduction 1 Development of Gestational Stem Cells 2 Isolation and Characterization of Amniotic Fluid Stem Cells 2 Multipotency of Amniotic Fluid Stem Cells 3 Clinical Application of Amniotic Fluid Stem Cells 8 Conclusion 13 References 13 2 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE 17 Richard L. Haspel and Karen K. Ballen Introduction 17 Hematopoietic Stem Cell Transplants: Adult Donor Collection 17 Hematopoietic Stem Cell Transplants: HLA Matching 18 Collection and Processing of Cord Blood Units 19 Hematopoietic Stem Cell Transplants: Recipient Issues 20 Bone Marrow versus Single Cord Blood: Pediatric 21 Bone Marrow versus Cord Blood: Adults 23 Cord Blood Transplant: Advantages and Disadvantages 23 Double Cord Blood Transplants: Ablative Regimens 24 Double Cord Blood Transplant: Non-Myeloablative Regimens 26 Are Two Cords Better Than One? 27 Chimerism 28 Predicting the Winner 28 Other Experimental Strategies 30 Summary 31 References 31 3 HEMATOPOIETIC STEM CELL DEVELOPMENT IN THE PLACENTA 37 Katrin E.R. Ericson, Akanksha Chhabra, and Hanna K.A. Mikkola Introduction 37 The Hematopoietic System 37 Historical Perspective on Placental Hematopoiesis 38 The Development and S...
