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At its present rate of growth, atherosclerosis will be the major cause of death from disease by the year 2020. Atherosclerosis is an extremely complex, biochemical, multifactorial process. This book will cover many aspects of atherogenesis, with particular emphasis on lipid and lipoprotein metabolism. We will cover all aspects of the regulation of cholesterol homeostasis and the importance of each pathway. This book will explore the role of nuclear hormone receptors on lipid and lipoprotein metabolism and their complex roles in atherogenesis. Finally, how the use of genetic studies can help sort out the immense complexities that mediate these aspects of atherogenesis will be discussed.
List of contents
The role of HDL in the prevention of atherosclerosis.- Cholesterol breakdown and the significance in atherosclerosis.- Triacylglycerol hydrolase, VLDL assembly and development of atherosclerosis.- Regulation of Hepatic Production of Lipoproteins Containing Apolipoprotein B and the significance in atherosclerosis.- Dyslipidemia and thrombogenesis.- Mouse models of Diabetes and Atherosclerosis.- Role of the unfolded protein response in atherosclerosis: a potential unifying theory of atherogenesis.- SR-BI, reverse cholesterol transport and atherogenesis.- Hypertension and atherosclerosis.- Dietary fats, transcription factors and heart health.- Dietary fatty acid intake and stroke.- Homocysteine metabolism and atherosclerosis.- Vitamin supplements in preventing atherosclerosis.- Oxidized lipids and heart disease.- Reverse cholesterol transport and prevention of atherosclerosis.- Homocysteine, diabetes mellitus and atherosclerosis.- Treating low HDL-From bench to bedside.- Atherosclerosis is an infectious disease.
About the author
Dr. Sukhinder K. Cheema is Associate Professor of Biochemistry, Memorial University of Newfoundland, Canada. She has worked as a Research Scientist with the Nova-Husky Research Corporation in Alberta, Canada. She is currently researching the molecular mechanisms of cholesterol ester transfer protein regulation by dietary fats and hormones. She also researches the regulation of genes involved in cholesterol metabolism by hormone factors, the molecular basis of diabetes-accelerated atherosclerosis, and the mechanisms of lipid abnormalities caused by protease inhibitors.
Summary
At its present rate of growth, atherosclerosis will be the major cause of death from disease by the year 2020. Atherosclerosis is an extremely complex, biochemical, multifactorial process. This book will cover many aspects of atherogenesis, with particular emphasis on lipid and lipoprotein metabolism. We will cover all aspects of the regulation of cholesterol homeostasis and the importance of each pathway. This book will explore the role of nuclear hormone receptors on lipid and lipoprotein metabolism and their complex roles in atherogenesis. Finally, how the use of genetic studies can help sort out the immense complexities that mediate these aspects of atherogenesis will be discussed.
