Computational Neuroscience - Simulated Demyelinating Neuropathies and Neuronopathies

Informationen zum Autor Stephanova! Diana Ivanova; Kolev! Bozhidar Dimitrov Zusammenfassung This book covers the computer simulation of demyelinating neuropathies and neuronopathies and compares models with clinical findings. Inhaltsverzeichnis NERVE FIBRES: Myelinated Axons. Demyelinating Neuropathies. Neuronopathies. Axonal Excitability.Mathematical Modeling of the Nerve Fibres. MODELS AND METHODS FOR INVESTIGATION OF THE HUMAN MOTOR NERVE FIBRE: Multi-Layered and Double Cable Models. Line-Source Model. Methods of Stimulation and Calculation of the Potentials. Methods for Calculation of the Strength-Duration Time. Constants! Rheobasic Currents and Recovery Cycles. SIMULATED DEMYELINATING NEUROPATHIES AND NEURONOPATHIES: Simulation of CMT1A! CIDP! Subtypes CIDP! GBS! MMN! and ALS. Abnormalities in the Potentials Action Potentials. Electrotonic Potentials. Abnormalities in the Extracellular Potentials and their Mechanisms. Abnormalities in the Strength-Duration Time Constants! Rheobasic Currents and Their Mechanisms. Abnormalities in the Recovery Cycles and Their Mechanisms. EFFECT OF THE MYELIN SHEATH AQUEOUS LAYERS ON THE EXCITABILITY PROPERTIES OF THE SIMULATED HEREDITARY AND CHRONIC DEMYELINATING NEUROPATHIES: Simulation of the CMT1A! CIDP and Subtypes CIDP with Aqueous Layers within the Myelin Sheath. Effect of the Myelin Sheath Aqueous Layers on the Potentials. Effect of the Myelin Sheath Aqueous Layers on the Strength-Duration Time Constants! Rheobasic Currents and Recovery Cycles. References.

Product details

• Authors: Bozhidar Dimitrov Kolev, Bozhidar Dimitrov (Institute for Population and Human Studies Kolev, Kolev Bozhidar Dimitrov, Diana Ivanova Stephanova, Diana Ivanova (Institute of Biophysics Stephanova, Diana Ivanova (Institute of Biophysics and Biomedical Engineering Stephanova, Diana Ivanova Kolev Stephanova, Stephanova Diana Ivanova
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Hardback
• Released: 23.01.2013
• EAN: 9781466578326
• ISBN: 978-1-4665-7832-6
• No. of pages: 148
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Medicine: general issues, SCIENCE / Life Sciences / General, SCIENCE / Life Sciences / Neuroscience, SCIENCE / Life Sciences / Biology, MEDICAL / Neurology, Neurology & clinical neurophysiology, Neurosciences, Neurology and clinical neurophysiology