Palladium in Organic Synthesis

Palladium is a remarkable metal. In particular, organopalladium chemistry has made remarkable progress over the last 30 years. That progress is still continuing, without any end in sight. This book presents a number of accounts and reviews on the novel Pd-catalyzed reactions discovered mainly in the last five years. The book covers Pd-catalyzed reactions that are new - entirely different from the more standard ones. Topics such as new reactions involving ß-carbon elimination and formation of palladacycles as key reactions, cross-coupling of unactivated alkyl electrophiles with organometallic compounds, arylation via C-H bond cleavage, Pd/norbornene-catalyzed aromatic functionalizations, three-component cyclizations of allenes, use of N-heterocyclic carbenes as ligands, asymmetric reactions catalyzed by Pd(II) compounds such as Lewis acids, cycloadditions of arynes and alkynes, and nucleophilic attack by Pd species are surveyed in detail by researchers who have made important contributions to these fields. The book addresses graduate students majoring in organic synthesis and researchers in academic and industrial institutes.

List of contents

T. Satoh, M. Miura: Catalytic Processes Involving b-Carbon Elimination.- M. Catellani: Novel Methods of Aromatic Functionalization Using Palladium and Norbornene as a Unique Catalytic System.- M. Miura, T. Satoh: Arylation Reactions via C-H Bond Cleavage.- M.R. Netherton, G.C. Fu: Palladium-Catalyzed Cross-Coupling Reactions of Unactivated Alkyl Electrophiles with Organometallic Compounds.- E. Guitián, D. Pérez and D. Peña: Palladium-Catalyzed Cycloaddition Reactions of Arynes.- R.C. Larock: Palladium-Catalyzed Annulation of Alkynes.- S. Ma: Palladium-Catalyzed Two- or Three-Component Cyclization of Functionalized Allenes.- Y. Yamamoto, I. Nakamura: Nucleophilic Attack by Palladium Species.- M.S. Viciu, S.P. Nolan: The Use of N-Heterocyclic Carbenes as Ligands in Palladium-Mediated Catalysis.- M. Mikami, M. Hatano and K. Akiyama: Active Pd(II) Complexes as Either Lewis Acid Catalysts or Transition Metal Catalysts

Summary

Palladium is a remarkable metal. In particular, organopalladium chemistry has made remarkable progress over the last 30 years. That progress is still continuing, without any end in sight. This book presents a number of accounts and reviews on the novel Pd-catalyzed reactions discovered mainly in the last five years. The book covers Pd-catalyzed reactions that are new – entirely different from the more standard ones. Topics such as new reactions involving ß-carbon elimination and formation of palladacycles as key reactions, cross-coupling of unactivated alkyl electrophiles with organometallic compounds, arylation via C-H bond cleavage, Pd/norbornene-catalyzed aromatic functionalizations, three-component cyclizations of allenes, use of N-heterocyclic carbenes as ligands, asymmetric reactions catalyzed by Pd(II) compounds such as Lewis acids, cycloadditions of arynes and alkynes, and nucleophilic attack by Pd species are surveyed in detail by researchers who have made important contributions to these fields. The book addresses graduate students majoring in organic synthesis and researchers in academic and industrial institutes.

Additional text

From the reviews:
"This book is timely, with references up to 2004, and illustrates the synthetic potential of organopalladium chemistry and the infinite number of catalytic processes that can be derived from the unique properties of this metal. It is a valuable resource that will be of particular interest to practitioners in this field. As only a few of the chapters introduce basic knowledge on organometallic processes, readers familiar with organopalladium chemistry will have a greater understanding and appreciation of the novel catalytic processes presented in this book. Nonetheless, this excellent monograph should be added to institutional libraries, since the prohibitive cost makes the book inaccessible to most faculty members and graduate students. An electronic version of Topics in Organometallic Chemistry is also offered, which allows access to individual chapters as pdf files."
J. Am. Chem. Soc. 2006, 128, 9574
Eric Fillion, University of Waterloo
"Over the last 20 years palladium-catalysed reactions have found many applications in chemical synthesis and the most recent advances over the last five years in palladium-catalysed carbon-carbon bond formation are found in this volume. … The chemistry in each chapter is supported and illustrated with examples and applications … . This is a highly recommended monograph on palladium catalysis for organic chemists." (Helmut Hügel, Chemistry in Australia, December, 2005)

Report

From the reviews:
"This book is timely, with references up to 2004, and illustrates the synthetic potential of organopalladium chemistry and the infinite number of catalytic processes that can be derived from the unique properties of this metal. It is a valuable resource that will be of particular interest to practitioners in this field. As only a few of the chapters introduce basic knowledge on organometallic processes, readers familiar with organopalladium chemistry will have a greater understanding and appreciation of the novel catalytic processes presented in this book. Nonetheless, this excellent monograph should be added to institutional libraries, since the prohibitive cost makes the book inaccessible to most faculty members and graduate students. An electronic version of Topics in Organometallic Chemistry is also offered, which allows access to individual chapters as pdf files."
J. Am. Chem. Soc. 2006, 128, 9574
Eric Fillion, University of Waterloo
"Over the last 20 years palladium-catalysed reactions have found many applications in chemical synthesis and the most recent advances over the last five years in palladium-catalysed carbon-carbon bond formation are found in this volume. ... The chemistry in each chapter is supported and illustrated with examples and applications ... . This is a highly recommended monograph on palladium catalysis for organic chemists." (Helmut Hügel, Chemistry in Australia, December, 2005)

Product details

• Assisted by: Jir Tsuji (Editor), Jiro Tsuji (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 13.10.2010
• EAN: 9783642063084
• ISBN: 978-3-642-06308-4
• No. of pages: 334
• Dimensions: 157 mm x 20 mm x 236 mm
• Weight: 521 g
• Illustrations: X, 334 p.
• Series: Topics in Organometallic Chemistry; Topics in Organometallic Chemistry
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Anorganische Chemie, C, Medizinische Chemie, Pharmazeutische Chemie, ORGANOMETALLIC CHEMISTRY, Katalyse, biochemistry, Catalysis, Chemistry and Materials Science, Inorganic Chemistry, MEDICINAL CHEMISTRY