Functional Neural Transplantation III - Primary and Stem Cell Therapies for Brain Repair

Informationen zum Autor Dunnett is a behavioural neuroscientist who started a lifelong collaboration with the Björklund team in 1979 to explore the functional consequences of cell transplantation method in animal models of neurodegenerative disease, in particular involving cell replacement and repair of the basal ganglia. He has developed models and novel methods of motor and cognitive assessment to apply behavioural analysis not simply to assess functional efficacy of implanted cells, but as a tool to study the mechanisms of cell integration, circuit reconstruction and functional repair. In parallel his laboratory originated the first UK trial of cell transplantation in Huntington’s disease, and provides the source of clinical grade cells for further ongoing trials in Parkinson’s disease. As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund’s lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson’s disease) in patients Klappentext This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery. Inhaltsverzeichnis Preface Stephen Dunnett and Anders Björklund Transplantation in the Future Fred H. Gage Stroke Neural Differentiation and Support of Neuroregeneration of Non-Neural Adult Stem Cells Rojin Abraham and Catherine M. Verfaillie Stem Cell Repair of Striatal Ischemia Zaal Kokaia and Olle Lindvall In-vivo Imaging of Cell Transplants in Experimental Ischemia Joanna Adamczak and Mathias Hoehn Bone Marrow Stem Cells in Experimental Stroke Jeffery D. Kocsis and Osamu Honmou Advantages and Challenges of Alternative Sources of Adult-Derived Stem Cells for Brain Repair in Stroke Paul R. Sanberg, David J. Eve, Christopher Metcalf and Cesario V. Borlongan Prospects for Stem Cell-Derived Therapy in Stroke John D. Sinden, Indira Vishnubhatla and Keith W. Muir Retinal and Cortical Repair Generation of Retinal Cells from Pluripotent Stem Cells Zi-Bing Jin and Masayo Takahashi Generation of Cortical Neurons from Pluripotent Stem Cells Pierre Vanderhaeghen Spinal Cord Repair A Glio-Centric View of Repair Ying Li, Daqing Li and Geoffrey Raisman Current Status of Myelin Replacement Therapies in Multiple Sclerosis Jeffrey K. Huang and Robin J.M. Franklin Stem Cell-Based Treatments for Spinal Cord Injury Lindsey A. Wyatt and Hans S. Keirstead The challenges of Long-Distance Axon Regeneration in the Injured CNS Daniel J. Chew, James W. Fawcett and Melissa R. Andrews Schwann Cell Transplantation: A Repair Strategy for Spinal Cord Injury? Ryan R. Wiliams and Mary Bartlett Bunge ...

List of contents

1. Preface
Stephen Dunnett and Anders Björklund


2. Transplantation in the Future
Fred H. Gage
Stroke


3. Neural Differentiation and Support of Neuroregeneration of Non-Neural Adult Stem Cells
Rojin Abraham and Catherine M. Verfaillie


4. Stem Cell Repair of Striatal Ischemia
Zaal Kokaia and Olle Lindvall


5. In-vivo Imaging of Cell Transplants in Experimental Ischemia
Joanna Adamczak and Mathias Hoehn


6. Bone Marrow Stem Cells in Experimental Stroke
Jeffery D. Kocsis and Osamu Honmou


7. Advantages and Challenges of Alternative Sources of Adult-Derived Stem Cells for Brain Repair in Stroke
Paul R. Sanberg, David J. Eve, Christopher Metcalf and Cesario V. Borlongan


8. Prospects for Stem Cell-Derived Therapy in Stroke
John D. Sinden, Indira Vishnubhatla and Keith W. Muir
Retinal and Cortical Repair


9. Generation of Retinal Cells from Pluripotent Stem Cells
Zi-Bing Jin and Masayo Takahashi


10. Generation of Cortical Neurons from Pluripotent Stem Cells
Pierre Vanderhaeghen
Spinal Cord Repair


11. A Glio-Centric View of Repair
Ying Li, Daqing Li and Geoffrey Raisman


12. Current Status of Myelin Replacement Therapies in Multiple Sclerosis
Jeffrey K. Huang and Robin J.M. Franklin


13. Stem Cell-Based Treatments for Spinal Cord Injury
Lindsey A. Wyatt and Hans S. Keirstead


14. The challenges of Long-Distance Axon Regeneration in the Injured CNS
Daniel J. Chew, James W. Fawcett and Melissa R. Andrews


15. Schwann Cell Transplantation: A Repair Strategy for Spinal Cord Injury?
Ryan R. Wiliams and Mary Bartlett Bunge


16. Generation of Motor Neurons from Pluripotent Stem Cells
Peter H. Chipman, Jeremy S. Toma and Victor F. Rafuse


17. Transplantation of Mesenchymal Stem Cells in ALS
    
    Letizia Mazzini, Alessandro Vercelli, Ivana Ferrero, Marina Boido, Roberto Cantello and Franca Fagioli

Product details

• Assisted by: Anders Bjorklund (Editor), Stephen B Dunnett (Editor), Stephen B. Dunnett (Editor)
• Publisher: ELSEVIER SCIENCE BV
• Languages: English
• Product format: Hardback
• Released: 01.12.2012
• EAN: 9780444595447
• ISBN: 978-0-444-59544-7
• No. of pages: 408
• Series: Progress in Brain Research; Progress in Brain Research
• Subjects: Natural sciences, medicine, IT, technology > Medicine > General; neurosurgery, MEDICAL / Surgery / Neurosurgery, MEDICAL / Surgery / Transplant, Transplant Surgery