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Providing a survey on current research in eukaryotic signal transduction, some of the topics covered are, the biochemistry and biophysics of cell surface receptors, G-protein mediated signalling pathways, regulation of cyclic AMP, Ca2+, inositol phosphate pathways, the structure and regulation of receptors which are tyrosine protein kinases, and cellular responses to integrated signals.
List of contents
I. Receptor Characteristics, Function and Regulation.- The nicotinic acetylcholine receptor: a member of the superfamily of ligand-gated ion channels.- Epidermal growth factor receptor autophosphorylation is not required for normal mitogenic or transforming signal generation.- The epidermal growth factor receptor: receptor dimerization and signal transduction.- Dimerization activates the epidermal growth factor receptor tyrosine kinase.- Insulin-related peptides and their receptor(s) in the mollusc, Lymnaea stagnalis.- Hepatic vasopressin receptor: a key receptor of phosphoinositide metabolism.- Gene targeting by homologous recombination as a tool to study the biophysical role of the interferon-? signalling pathway.- Expression of novel cloned rat pituitary receptors in mammalian cells.- Cellular localization of seven transmembrane domain receptor mRNA's by in-situ hybridization.- The T cell activation molecule CD27 is a member of the nerve growth factor receptor gene family.- Membrane receptor clustering as a cellular stimulus - the mast cell case.- II. G-Proteins and Protein Kinases.- G protein-coupled receptors: structural basis of selective signaling.- Hormone receptor-effector coupling in prolactin producing pituitary cell lines (GH cells)..- Effect of aging on the ?-adrenergic signal transduction system in rat kidney, lung, and mononuclear leukocytes.- The transducin cycle in the phototransduction cascade.- Expression of two isoforms of the guanine nucleotide binding protein, G0, in NG108-15 neuroglioma cells.- Mechanisms underlying hormonal modification of dopamine receptor sensitivity.- Phosphorylation of the growth factor activatable Na+/H+ antiporter: a mechanism of regulation.- Overexpression of protein kinase C ? in Swiss/3T3 cells reduces thenumber of both high and low affinity of the epidermal growth factor receptors.- Characterization of protein kinase C isoforms in a small cell lung carcinoma cell line: regulation of PKC? and its catalytic fragment.- The human type I cGMP-dependent protein kinase gene.- Control of cellular activity by protein phosphorylation-dephosphorylation: Phosphorylase kinase from bovine stomach smooth muscle.- III. Surface Membrane Components.- Properties of phosphoinositides in membranes.- Glycosyl-phosphatidylinositol membrane anchors.- Cell adhesion in morphogenesis.- IV. Inositol Phosphate and Calcium.- Inositol phosphate metabolism and function.- Inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakiphosphate: functions, metabolism and interconversion.- Histamine H1-receptor-mediated breakdown of inositol phospholipids in primary neuronal cultures.- Intracellular Ca2+ homeostasis: receptor-activated Ca2+ channels and intracellular Ca2+ pools.- Multiple sources of sn-1,2-diacylglycerol in mitogen-stimulated Swiss 3T3 cells: evidence for activation of phosphoinositidase C and phospholipase D.- Phorbol esters and muscarinic receptor agonists activate phospholipase D in heart and brain.- V. Release Reactions and Protein Sorting.- Development of a single cell Ca2+ imaging system to study the role of PKC substrate B-50 in neurotransmitter release and neurite outgrowth.- Regulated exocytosis as a paradigm of biological signal transduction.- Mannose 6-phosphate receptors and their role in protein sorting along the pathway to lysosomes.- Protein sorting in endosomes.- VI. Addendum.- Note to the addendum.- Guanylate cyclase in signal transduction of Dictyosteliwn a iscoideum.- Epidermal growth factor mediated signal transduction in rat hepatocytes.
